studyonmetabonomeinhumanserumwithhepatocellularcarcinomaorlivercirrhosis
文献类型：期刊论文
| 作者 | Lu Q(陆强)1; Huang YH(黄一红)1; Cong H(丛辉)1; Liu X(刘霞)2 ; Gao HC(高红昌)2; Lin DH(林东海)2; Wang HM(王惠民)1
|
| 刊名 | chinesejournalofanalyticalchemistry
 |
| 出版日期 | 2009 |
| 卷号 | 37期号:2页码:194 |
| 关键词 | BLOOD-PLASMA SPECTROSCOPY Hepatocellular carcinoma liver cirrhosis serum metabonome nuclear magnetic resonance spectroscopy pattern recognition |
| ISSN号 | 0253-3820 |
| 英文摘要 | A comparison for the metabonome in serum samples from patients of LC(liver cirrhosis), HCC(hepatocellular carcinoma) and healthy volunteers were studied with the method of NMR(nuclear magnetic resonance spectroscopy). To explore the potential of applying H-1 NMR-based metabonomics to diagnose HCC, PLS-DA (partial least square-discriminant analysis) was employed to perform the pattern recognition analysis of NMR spectra. In comparison with healthy volunteers, the result show that patients of LC and HCC were characterized by depleted levels of lipids (LDL, low-density lipoprotein and VLDL, very low-density lipoprotein), choline, acetoacetate, etc. and by elevated levels of glutamine, pyruvate, phenylalanine, tyrosine, etc.. The results of PLS-DA analysis shows that HCC patients could be discriminated from healthy volunteers and LC patients with diagnositic sensitivity of 92.1% and false positive rate of 5.7% These were better than the results of serum AFP (alpha-fetoprotein) detection. The results also show that H-1 NMR-based metabonomics couple with PLS-DA analysis is useful for clinical diagnosis of HCC, and the method has the superiorities of sensitiveness, accuracy and good reproducibility. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287182]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.南通大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Lu Q,Huang YH,Cong H,et al. studyonmetabonomeinhumanserumwithhepatocellularcarcinomaorlivercirrhosis[J]. chinesejournalofanalyticalchemistry,2009,37(2):194. |
| APA | 陆强.,黄一红.,丛辉.,刘霞.,高红昌.,...&王惠民.(2009).studyonmetabonomeinhumanserumwithhepatocellularcarcinomaorlivercirrhosis.chinesejournalofanalyticalchemistry,37(2),194. |
| MLA | 陆强,et al."studyonmetabonomeinhumanserumwithhepatocellularcarcinomaorlivercirrhosis".chinesejournalofanalyticalchemistry 37.2(2009):194. |
入库方式： OAI收割
来源：上海药物研究所
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