designsynthesisandantibacterialactivityofnovelpleuromutilinderivativeswith4hpyran4oneandpyridin4onesubstitutioninthec14sidechain
文献类型：期刊论文
| 作者 | Ling Chenyu1; Tao Yunliang2; Chu Wenjing1; Wang Hui3; Wang Haidong2; Yang Yushe1
|
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:2页码:235 |
| ISSN号 | 1001-8417 |
| 关键词 | INFECTIOUS-DISEASES SOCIETY AMERICA AGENTS Multi-drug resistant bacteria Pleuromutilin 4H-Pyran-4-one Antibacterial activity |
| DOI | 10.1016/j.cclei.2015.09.019 |
| 英文摘要 | A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of the derivatives exhibited potent antibacterial activity against drug resistant Gram-positive strains. Compounds 12a, 12d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781. As the metabolic stability of this series is not satisfactory, further modifications are going on to improve their pharmacokinetic profile. (C) 2015 Chinese Chemical Society and Institute of Materia Medics, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287478]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.常州大学 3.中国药科大学 |
| 推荐引用方式 GB/T 7714 | Ling Chenyu,Tao Yunliang,Chu Wenjing,et al. designsynthesisandantibacterialactivityofnovelpleuromutilinderivativeswith4hpyran4oneandpyridin4onesubstitutioninthec14sidechain[J]. chinesechemicalletters,2016,27(2):235. |
| APA | Ling Chenyu,Tao Yunliang,Chu Wenjing,Wang Hui,Wang Haidong,&Yang Yushe.(2016).designsynthesisandantibacterialactivityofnovelpleuromutilinderivativeswith4hpyran4oneandpyridin4onesubstitutioninthec14sidechain.chinesechemicalletters,27(2),235. |
| MLA | Ling Chenyu,et al."designsynthesisandantibacterialactivityofnovelpleuromutilinderivativeswith4hpyran4oneandpyridin4onesubstitutioninthec14sidechain".chinesechemicalletters 27.2(2016):235. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。