Nuclear-targeting TAT-PEG-Asp_8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer
文献类型：期刊论文
| 作者 | Pan Zhenzhen2; Wang Huiyuan2 ; Zhang Meng2; Lin Tingting2; Zhang Wenyuan2; Zhao Pengfei2; Tang Yisi2; Xiong Yong1; Zeng Yuaner3; Huang Yongzhuo2
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| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2016 |
| 卷号 | 37期号:8页码:1110 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES CELL PENETRATING PEPTIDES MULTIDRUG-RESISTANCE P-GLYCOPROTEIN PLGA NANOPARTICLES COLORECTAL-CANCER BREAST-CANCER DELIVERY CHEMOTHERAPY INHIBITION doxorubicin multidrug resistance cell-penetrating peptide poly(aspartic acid) intranuclear delivery nanoparticles human colon cancer HCT8/ADR cells |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2016.48 |
| 英文摘要 | Aim: Drug efflux-associated multidrug resistance (MDR) is a main obstacle to effective cancer chemotherapy. Large molecule drugs are not the substrates of P-glycoprotein, and can circumvent drug efflux and be retained inside cells. In this article we report a polymer-drug conjugate nanoparticulate system that can overcome MDR based on size-related exclusion effect. |
| 资助项目 | [973 Program, China] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287503]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Jiaotong University Affiliated Sixth People's Hospital 2.中国科学院上海药物研究所 3.广州中医药大学 |
| 推荐引用方式 GB/T 7714 | Pan Zhenzhen,Wang Huiyuan,Zhang Meng,et al. Nuclear-targeting TAT-PEG-Asp_8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer[J]. Acta Pharmacologica Sinica,2016,37(8):1110. |
| APA | Pan Zhenzhen.,Wang Huiyuan.,Zhang Meng.,Lin Tingting.,Zhang Wenyuan.,...&Huang Yongzhuo.(2016).Nuclear-targeting TAT-PEG-Asp_8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer.Acta Pharmacologica Sinica,37(8),1110. |
| MLA | Pan Zhenzhen,et al."Nuclear-targeting TAT-PEG-Asp_8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer".Acta Pharmacologica Sinica 37.8(2016):1110. |
入库方式： OAI收割
来源：上海药物研究所
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