biomimeticalbuminmodifiedgoldnanorodsforphotothermochemotherapyandmacrophagepolarizationmodulation
文献类型：期刊论文
| 作者 | Li Dongdong; Zhang Meng; Xu Fan; Chen Yingzhi; Chen Binfan; Chang Ya; Zhong Huihai; Jin Hongyue; Huang Yongzhuo
|
| 刊名 | actapharmaceuticasinicab
 |
| 出版日期 | 2018 |
| 卷号 | 000期号:001页码:74 |
| 关键词 | Photothermal therapy Paclitaxel Combination therapy Gold nanorods Albumin Tumor-associated macrophage |
| ISSN号 | 2211-3835 |
| 英文摘要 | Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods(AuNRs) were prepared with incorporation of paclitaxel(PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287805]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Li Dongdong,Zhang Meng,Xu Fan,et al. biomimeticalbuminmodifiedgoldnanorodsforphotothermochemotherapyandmacrophagepolarizationmodulation[J]. actapharmaceuticasinicab,2018,000(001):74. |
| APA | Li Dongdong.,Zhang Meng.,Xu Fan.,Chen Yingzhi.,Chen Binfan.,...&Huang Yongzhuo.(2018).biomimeticalbuminmodifiedgoldnanorodsforphotothermochemotherapyandmacrophagepolarizationmodulation.actapharmaceuticasinicab,000(001),74. |
| MLA | Li Dongdong,et al."biomimeticalbuminmodifiedgoldnanorodsforphotothermochemotherapyandmacrophagepolarizationmodulation".actapharmaceuticasinicab 000.001(2018):74. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。