designsynthesisandbiologicalevaluationofbiphenylureaderivativesasvegfr2kinaseinhibitorsii
文献类型：期刊论文
| 作者 | Gao Guorui1; Li Mengyuan2; Lv Yongcong2; Cao Sufen1; Tong Linjiang2; Wei Lixin3; Ding Jian2 ; Xie Hua2; Duan Wenhu1
|
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:2页码:200 |
| 关键词 | GROWTH-FACTOR RECEPTOR-2 POTENT ANGIOGENESIS DISCOVERY SORAFENIB TOXICITY CANCER Angiogenesis Kinase Inhibitor VEGFR-2 |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2015.10.004 |
| 英文摘要 | Inhibition of VEGFR-2 signaling pathway is one of the most promising approaches for the treatment of cancer. In this paper, we reported the design, synthesis, and biological evaluation of a series of biphenylurea derivatives as VEGFR-2 inhibitors. Among these compounds, 39 exhibited potent inhibitory activity against VEGFR-2 both in vitro and in vivo. The antiangiogenesis activity of 39 was further confirmed by both tube formation assay and chick chorioallantoic membrane assay. (c) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] ; [National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"] ; [Chinese National Programs for High Technology Research and Development] ; [Shanghai Science and Technology Commission] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287878]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.华东理工大学 2.中国科学院上海药物研究所 3.中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Gao Guorui,Li Mengyuan,Lv Yongcong,et al. designsynthesisandbiologicalevaluationofbiphenylureaderivativesasvegfr2kinaseinhibitorsii[J]. chinesechemicalletters,2016,27(2):200. |
| APA | Gao Guorui.,Li Mengyuan.,Lv Yongcong.,Cao Sufen.,Tong Linjiang.,...&Duan Wenhu.(2016).designsynthesisandbiologicalevaluationofbiphenylureaderivativesasvegfr2kinaseinhibitorsii.chinesechemicalletters,27(2),200. |
| MLA | Gao Guorui,et al."designsynthesisandbiologicalevaluationofbiphenylureaderivativesasvegfr2kinaseinhibitorsii".chinesechemicalletters 27.2(2016):200. |
入库方式： OAI收割
来源：上海药物研究所
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