spectroscopicstudiesofaripiprazole
文献类型：期刊论文
| 作者 | Li JF(李剑峰)1 ; Liu AX(刘爱祥)1; Xia GX(夏广新)1; Nian YF(年亦丰)2; Shen JS(沈敬山)1
|
| 刊名 | spectroscopyandspectralanalysis
 |
| 出版日期 | 2007 |
| 卷号 | 27期号:5页码:863 |
| 关键词 | SPECTRA aripiprazole ultraviolet spectrum infrared spectrum nuclear magnetic resonance mass spectrum structure identification |
| ISSN号 | 1000-0593 |
| 英文摘要 | The ultraviolet spectrum (UV), infrared spectrum (IR), nuclear magnetic resonance (NMR) and mass spectrum (MS) of aripiprazole, a new antipsychotic drug, were reported and interpreted. The structure of aripiprazole in solution was studied according to the UV spectra detected in solution with different pH values. The vibrations of functional groups of this compound in IR and the isotopic ion peaks in MS were discussed. Moreover, the 2D-NMR techniques, including H-1-H-1 correlation spectroscopy (H-1-H-1 cosy), heteronuclear single-quantum coherence (HSQC), and heteronuclear multiple-bond correlation (HMBC), were used to deduce the structure of this compound. All the H-1 NMR. and C-13 NMR signals were assigned. Especially, the ten different methylenes in this structure were analyzed according to the chemical shifts, coupling constants and correlations in 2D-NMR spectrum. By all these spectral techniques, the structure of aripiprazole was identified. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287909]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.上海特化医药科技有限公司 |
| 推荐引用方式 GB/T 7714 | Li JF,Liu AX,Xia GX,et al. spectroscopicstudiesofaripiprazole[J]. spectroscopyandspectralanalysis,2007,27(5):863. |
| APA | 李剑峰,刘爱祥,夏广新,年亦丰,&沈敬山.(2007).spectroscopicstudiesofaripiprazole.spectroscopyandspectralanalysis,27(5),863. |
| MLA | 李剑峰,et al."spectroscopicstudiesofaripiprazole".spectroscopyandspectralanalysis 27.5(2007):863. |
入库方式： OAI收割
来源：上海药物研究所
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