excretionof3htriptolideanditsmetabolitesinratsafteroraladministration
文献类型：期刊论文
| 作者 | Liu Jia ; Zhou Xin; Chen Xiaoyan; Zhong Dafang
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:4页码:549 |
| 关键词 | triptolide immunosuppressant pharmacokinetics excretion pathway gender difference |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To investigate the routes of elimination and excretion for triptolide recovered in rats. Methods: After a single oral administration of ~3Htriptolide (0.8 mg/kg, 100 μCi/kg) in Sprague Dawley rats, urine and fecal samples were collected for 168 h. To study biliary excretion, bile samples were collected for 24 h through bile duct cannulation. Radioactivity was measured using a liquid scintillation analyzer, and excretion pathway analysis was performed using an HPLC/on-line radioactivity detector. Results: The total radioactivity recovered from the urine and feces of rats without bile duct ligation ranged from 86.6%–89.1%. Most of the radioactivity (68.6%–72.0%) was recovered in the feces within 72 h after oral administration, while the radioactivity recovered in the urine and bile was 17.1%–18.0% and 39.0%–39.4%, respectively. The HPLC/on-line radiochromatographic analysis revealed that most of the drug-related radioactivity was in the form of metabolites. In addition, significant gender differences in the quantity of these metabolites were found: monohydroxytriptolide sulfates were the major metabolites detected in the urine, feces, and bile of female rats, while only traces of these metabolites were found in male rats. Conclusion: Radiolabeled triptolide is mainly secreted in bile and eliminated in feces. The absorbed radioactivity is primarily eliminated in the form of metabolites, and significant gender differences are observed in the quantity of recovered metabolites, which are likely caused by the gender-specific expression of sulfotransferases. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287922]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Liu Jia,Zhou Xin,Chen Xiaoyan,et al. excretionof3htriptolideanditsmetabolitesinratsafteroraladministration[J]. actapharmacologicasinica,2014,35(4):549. |
| APA | Liu Jia,Zhou Xin,Chen Xiaoyan,&Zhong Dafang.(2014).excretionof3htriptolideanditsmetabolitesinratsafteroraladministration.actapharmacologicasinica,35(4),549. |
| MLA | Liu Jia,et al."excretionof3htriptolideanditsmetabolitesinratsafteroraladministration".actapharmacologicasinica 35.4(2014):549. |
入库方式： OAI收割
来源：上海药物研究所
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