twonewcoumarinsfromfraxinuschinensisrexb
文献类型：期刊论文
| 作者 | DongMei Zhang1; LiLi Wang1; Jia Li2 ; LiHong Hu1
|
| 刊名 | journalofintegrativeplantbiology
 |
| 出版日期 | 2007 |
| 卷号 | 49期号:2页码:218 |
| 关键词 | GROWTH-FACTOR RECEPTOR-1 PROTEIN-KINASES INHIBITORS PROMOTES coumarins Fraxinus chinensis VEGF receptor-1 kinase |
| ISSN号 | 1672-9072 |
| DOI | 10.1111/j.1672-9072.2006.00340.x |
| 英文摘要 | The ethanol extract of the stem bark of Fraxinus chinensis Roxb. showed good inhibitory bioactivity against VEGF receptor-1 kinase (IC50: 13.8 mu g/mL). In order to find new and bioactive compounds, the chemical constituents of the stem bark of F. chinensis were investigated and two new coumarins, namely 6'-O-sinapinoyl esculin (compound 1) and 6'-O-vanillyl esculin (compound 2), together with eleven known compounds (compounds 3-13) were isolated. The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly one- and two-dimensional nuclear magnetic resonance spectral methods. The known compound, oleuropein (compound 11), exhibited moderate activity (IC50: (8.7 +/- 1.3) mu mol/L) to inhibit VEGF receptor-1 kinase. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288137]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | DongMei Zhang,LiLi Wang,Jia Li,et al. twonewcoumarinsfromfraxinuschinensisrexb[J]. journalofintegrativeplantbiology,2007,49(2):218. |
| APA | DongMei Zhang,LiLi Wang,Jia Li,&LiHong Hu.(2007).twonewcoumarinsfromfraxinuschinensisrexb.journalofintegrativeplantbiology,49(2),218. |
| MLA | DongMei Zhang,et al."twonewcoumarinsfromfraxinuschinensisrexb".journalofintegrativeplantbiology 49.2(2007):218. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。