nanotechnologybasedcombinationtherapyforovercomingmultidrugresistantcancer
文献类型：期刊论文
| 作者 | Zhang Meng; Liu Ergang; Cui Yanna; Huang Yongzhuo
|
| 刊名 | cancerbiologyandmedicine
 |
| 出版日期 | 2017 |
| 卷号 | 14期号:3页码:212 |
| 关键词 | CHEMO-PHOTOTHERMAL THERAPY DRUG-DELIVERY SYSTEM TARGETED CO-DELIVERY GLYCOPROTEIN MEDIATED EFFLUX BREAST-CANCER P-GLYCOPROTEIN IN-VITRO SILICA NANOPARTICLES OVARIAN-CANCER SURVIVORSHIP STATISTICS |
| ISSN号 | 2095-3941 |
| DOI | 10.20892/j.issn.2095-3941.2017.0054 |
| 英文摘要 | Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse. Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic (PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties (e.g., those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored. They possess great advantages for tumor targeting, controlled drug release, and identical drug PK profiles. Thus, a powerful tool for combination therapy is provided, and the translation from in vitro to in vivo is facilitated. In this review, we present a summary of various combination strategies for overcoming MDR and the nanotechnology-based combination therapy. |
| 资助项目 | [National Basic Research Program of China] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288151]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Meng,Liu Ergang,Cui Yanna,et al. nanotechnologybasedcombinationtherapyforovercomingmultidrugresistantcancer[J]. cancerbiologyandmedicine,2017,14(3):212. |
| APA | Zhang Meng,Liu Ergang,Cui Yanna,&Huang Yongzhuo.(2017).nanotechnologybasedcombinationtherapyforovercomingmultidrugresistantcancer.cancerbiologyandmedicine,14(3),212. |
| MLA | Zhang Meng,et al."nanotechnologybasedcombinationtherapyforovercomingmultidrugresistantcancer".cancerbiologyandmedicine 14.3(2017):212. |
入库方式： OAI收割
来源：上海药物研究所
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