electrophysiologicalactionsofcyclosporinaandtacrolimusonrathippocampalca1pyramidalneurons1
文献类型：期刊论文
| 作者 | Yong YU1; Xueqin CHEN2; Yaoyuan CUI1; Guoyuan HU2 |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:12页码:1891 |
| 关键词 | action potential calcineurin cyclosporin A delayed rectifier K+ channel hippocampus tacrolimus |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: The aim of the present study was to investigate the electrophysiological actions of cyclosporin A (CsA) and tacrolimus (FK506) on neurons in the brain, and to elucidate the relevant mechanisms. Methods: Whole-cell current-clamp recording was made in CA1 pyramidal neurons in rat hippocampal slices; whole-cell voltage-clamp recording was made in dissociated hippocampal CA1 pyramidal neurons of rats. Results: CsA (100 μmol/L) and FK506 (50 μmol/L) did not significantly alter the passive electrical properties of hippocampal CA1 pyramidal neurons, but slowed down the repolarizing phase of the action potential. CsA (10-100 μmol/L) selectively inhibited the delayed rectifier K~+ current (IK) in a concentration-dependent manner. CsA did not affect the kinetic properties of I_K. Intracellular dialysis of CsA (100 μmol/L) had no effect on I_K. The inhibition of IK by CsA (100 μmol/L) persisted under the low Ca~(2+) conditions that blocked the basal activity of calcineurin. Conclusion: CsA exerted calcineurin-independent inhibition on the IK in rat hippocampal pyramidal neurons. Taken together with our previous finding with FK506, it is conceivable that the spike broadening caused by the immunosuppressant drugs is due to direct inhibition on the IK. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288173]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.复旦大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Yong YU,Xueqin CHEN,Yaoyuan CUI,et al. electrophysiologicalactionsofcyclosporinaandtacrolimusonrathippocampalca1pyramidalneurons1[J]. actapharmacologicasinica,2007,28(12):1891. |
| APA | Yong YU,Xueqin CHEN,Yaoyuan CUI,&Guoyuan HU.(2007).electrophysiologicalactionsofcyclosporinaandtacrolimusonrathippocampalca1pyramidalneurons1.actapharmacologicasinica,28(12),1891. |
| MLA | Yong YU,et al."electrophysiologicalactionsofcyclosporinaandtacrolimusonrathippocampalca1pyramidalneurons1".actapharmacologicasinica 28.12(2007):1891. |
入库方式： OAI收割
来源：上海药物研究所
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