caspase3治疗神经退行性疾病的新靶点
文献类型：期刊论文
| 作者 | 张亚辉1; 李佳2 ; 周忠良1
|
| 刊名 | 生物化学与生物物理进展
 |
| 出版日期 | 2003 |
| 卷号 | 30期号:2页码:175 |
| 关键词 | TRAUMATIC BRAIN INJURY APOPTOSIS CLEAVAGE CELLS TAU caspase-3 inhibitors apoptosis neurodegenerative diseases |
| ISSN号 | 1000-3282 |
| 英文摘要 | Caspase-3, a member of the caspase family, is the key protein enzyme of mammalian cell in apoptosis. Recent studies show that caspase-3 plays an essential role in the pathological process of neurodegenerative diseases. In the process, caspase-3 not only performs as apoptosis effector, but also interacts directly with the pathogenic protein molecules of these diseases, such as Alzheimer's disease, Parkinson's disease, Huntington disease and Spinocerebellar ataxia, particpating in their pathogenic mechanism. Therefore, caspase-3 is a new target for neurodegenerative diseases treatment, the search for caspase-3 inhibitors with high effectivity and selectivity will supply a novel way to cure neurodegenerative diseases. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288403]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.华东师范大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | 张亚辉,李佳,周忠良. caspase3治疗神经退行性疾病的新靶点[J]. 生物化学与生物物理进展,2003,30(2):175. |
| APA | 张亚辉,李佳,&周忠良.(2003).caspase3治疗神经退行性疾病的新靶点.生物化学与生物物理进展,30(2),175. |
| MLA | 张亚辉,et al."caspase3治疗神经退行性疾病的新靶点".生物化学与生物物理进展 30.2(2003):175. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。