Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release
文献类型：期刊论文
| 作者 | Li Zhuo1; Li Haiyan2 ; Wang Caifen2; Xu Jianghui2; Singh Vikramjeet2; Chen Dawei1; Zhang Jiwen1
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| 刊名 | Acta Pharmaceutica Sinica B
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:4页码:344 |
| 关键词 | Vesicles Insulin Self-assembly Gel pH-selective release |
| ISSN号 | 2211-3835 |
| 英文摘要 | In an answer to the challenge of enzymatic instability and low oral bioavailability of proteins β -cyclodextrin ( β -CD) embedded in chitosan gel, was used to successfully deliver the model drug-insulin. The self-assembled SDS β -CD vesicles were prepared and characterized by particle size, zeta potential, appearance, microscopic morphology and entrapment efficiency. In addition, both the interaction of insulin with vesicles and the stability of insulin loaded in vesicles in the presence of pepsin were investigated. The vesicles were crosslinked into thermo-sensitive chitosan β -glycerol phosphate solution for an in-situ gel to enhance the dilution stability. The in vitro release characteristics of insulin from gels in media at different pH values were investigated. The insulin loaded vesicles–chitosan hydrogel (IVG) improved the dilution stability of the vesicles and provided pH-selective sustained release compared with insulin solution–chitosan hydrogel (ISG). In vitro , IVG exhibited slow release in acidic solution and relatively quick release in neutral solutions to provide drug efficacy. In simulated digestive fluid, IVG showed better sustained release and insulin protection properties compared with ISG. Thus IVG might improve the stability of insulin during its transport in vivo and contribute to the bioavailability and therapeutic effect of insulin. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288409]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.沈阳药科大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Li Zhuo,Li Haiyan,Wang Caifen,et al. Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release[J]. Acta Pharmaceutica Sinica B,2016,6(4):344. |
| APA | Li Zhuo.,Li Haiyan.,Wang Caifen.,Xu Jianghui.,Singh Vikramjeet.,...&Zhang Jiwen.(2016).Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release.Acta Pharmaceutica Sinica B,6(4),344. |
| MLA | Li Zhuo,et al."Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release".Acta Pharmaceutica Sinica B 6.4(2016):344. |
入库方式： OAI收割
来源：上海药物研究所
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