Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies
文献类型：期刊论文
| 作者 | Zhao, Qing1,2; Ren, Xia1,2; Chen, Min1,3; Yue, Shi-Jun1,2; Zhang, Meng-Qi1,2; Chen, Kai-Xian4,5 ; Guo, Yue-Wei4,5; Shao, Chang-Lun1,2; Wang, Chang-Yun1,2
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| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
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| 出版日期 | 2019-11-15 |
| 卷号 | 244页码:10 |
| ISSN号 | 0378-8741 |
| 关键词 | Traditional Chinese medicine Formula Le-Cao-Shi Hepatitis B virus Anti-Hepatitis B |
| DOI | 10.1016/j.jep.2019.112132 |
| 通讯作者 | Shao, Chang-Lun(shaochanglun@ouc.edu.cn) ; Wang, Chang-Yun(changyun@ouc.edu.cn) |
| 英文摘要 | Ethnopharmacological relevance: Formula Le-Cao-Shi (LCS) is a traditional Chinese medicine (TCM), which has long been used as a folk remedy against hepatitis B in China. The present study was conducted to evaluate the anti-hepatitis B effects of aqueous extract of LCS in vivo and in vitro. Materials and method: we investigated the anti-HBV effects of LCS in vivo and in vitro with duck hepatitis B model and HepG2.2.15 cell line model, respectively. The serologic and cellular biomarkers and the histopathological changes were examined. Results: By a duck hepatitis B model, the extract of LCS was found to restrain the expressions of duck hepatitis B surface antigen (DHBsAg), hepatitis B e antigen (DHBeAg), and HBV-DNA (DHBV-DNA). Moreover, LCS could decrease the levels of aspartate and alanine aminotransferases (AST and ALT) and ameliorate duck liver histological lesions. Correspondingly, in a HepG2.2.15 cellular model, LCS could also significantly inhibit the secretions of HBsAg and HBeAg. Conclusion: LCS exerted potent anti-hepatitis effects against the infection of HBV. The above results demonstrated the first-hand experimental evidences for the anti-hepatitis B efficiency of LCS. Our study provides a basis for further exploration and development of this promising compound prescription to treat hepatitis B disease. |
| WOS关键词 | ACANTHUS-ILICIFOLIUS L. ; CUDRANIA-COCHINCHINENSIS ; NUCLEOSIDE ANALOGS ; VIRUS ACTIVITY ; EXTRACT ; PHYTOCHEMISTRY ; ANTIOXIDANT ; GLYCOSIDES ; XANTHONES ; FEATURES |
| 资助项目 | National Natural Science Foundation of China[41806191] ; National Natural Science Foundation of China[U1606403] ; National High Technology Research and Development Program of China (863 Program)[2013AA093001] ; Marine S &T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0406-5] ; Taishan Scholars |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| 出版者 | ELSEVIER IRELAND LTD |
| WOS记录号 | WOS:000486357500018 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288542]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shao, Chang-Lun; Wang, Chang-Yun |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China 3.Yangzhou Univ, Coll Environm Sci & Engn, Marine Sci & Technol Inst, Yangzhou 225127, Jiangsu, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Shandong, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qing,Ren, Xia,Chen, Min,et al. Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,244:10. |
| APA | Zhao, Qing.,Ren, Xia.,Chen, Min.,Yue, Shi-Jun.,Zhang, Meng-Qi.,...&Wang, Chang-Yun.(2019).Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies.JOURNAL OF ETHNOPHARMACOLOGY,244,10. |
| MLA | Zhao, Qing,et al."Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies".JOURNAL OF ETHNOPHARMACOLOGY 244(2019):10. |
入库方式： OAI收割
来源：上海药物研究所
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