Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa
文献类型：期刊论文
| 作者 | Jiao, Wei-Hua1; Li, Jing1,2; Zhang, Meng-Meng3; Cui, Jie1; Gui, Yu-Han1; Zhang, Yun4; Li, Jing-Ya3 ; Liu, Ke-Chun4; Lin, Hou-Wen1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-08-16 |
| 卷号 | 21期号:16页码:6190-6193 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b01754 |
| 通讯作者 | Lin, Hou-Wen(franklin67@126.com) |
| 英文摘要 | The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 mu M. |
| WOS关键词 | TYROSINE-PHOSPHATASE 1B ; INHIBITORY-ACTIVITY ; INSULIN SENSITIVITY ; ALPHA-GLUCOSIDASE ; PTP1B ; SESQUITERPENOIDS ; ACIDS |
| 资助项目 | National Key Research and Development Program of China[2018YFC0310901] ; National Natural Science Foundation of China[41576130] ; National Natural Science Foundation of China[U160S221] ; National Natural Science Foundation of China[81602982] ; National Natural Science Foundation of China[81703624] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000481979100003 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288561]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lin, Hou-Wen |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, State Key Lab Oncogene & Related Genes,Res Ctr Ma, Shanghai 200127, Peoples R China 2.Shanghai Acad Agr Sci, Biotech Res Inst, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 4.Qilu Univ Technol, Inst Biol, Jinan 250103, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Wei-Hua,Li, Jing,Zhang, Meng-Meng,et al. Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa[J]. ORGANIC LETTERS,2019,21(16):6190-6193. |
| APA | Jiao, Wei-Hua.,Li, Jing.,Zhang, Meng-Meng.,Cui, Jie.,Gui, Yu-Han.,...&Lin, Hou-Wen.(2019).Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.ORGANIC LETTERS,21(16),6190-6193. |
| MLA | Jiao, Wei-Hua,et al."Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa".ORGANIC LETTERS 21.16(2019):6190-6193. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。