Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis
文献类型：期刊论文
| 作者 | Zhang, Pengcheng2,3,4 ; Zhai, Yihui2,3,4; Cai, Ying2,3,4; Zhao, Yuliang1,5; Li, Yaping2,3,4
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| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2019-09-30 |
| 页码 | 18 |
| 关键词 | cancer immunotherapy metastasis nanomaterials nanomedicine |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201904156 |
| 通讯作者 | Zhao, Yuliang(zhaoyl@nanoctr.cn) ; Li, Yaping(ypli@simm.ac.cn) |
| 英文摘要 | Metastasis is the leading cause of cancer-associated death, with poor prognosis even after extensive treatment. The dormancy of metastatic cancer cells during dissemination or after colony formation is one major reason for treatment failure, as most drugs target cells of active proliferation. Immunotherapy has shown great potential in cancer therapy because the activity of effector cells is less affected by the metabolic status of cancer cells. In addition, metastatic cells out of immunosuppressive tumor microenvironment (TME) are more susceptible to immune clearance, although these cells can achieve immune surveillance evasion via strategies such as platelet and macrophage recruitment. Since nanomaterials themselves or their carried drugs have the capability to modulate the immune system, a great amount of focus has been placed on nanomedicine strategies that leverage immune cells participating the metastatic cascade. These nanomedicines successfully inhibit the tumor metastasis and prolong the survival of model animals. Immune cells that are involved in the metastasis cascade are first summarized and then recent and inspiring strategies and nanomaterials in this growing field are highlighted. |
| WOS关键词 | TUMOR-ASSOCIATED MACROPHAGES ; IMMUNE CHECKPOINT BLOCKADE ; DRUG-DELIVERY ; MICROENVIRONMENTAL REGULATION ; ENGINEERED MATERIALS ; BONE METASTASIS ; DENDRITIC CELLS ; LUNG METASTASIS ; UP-REGULATION ; STEM-CELLS |
| 资助项目 | National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[31870995] ; National Natural Science Foundation of China[81671808] ; National Natural Science Foundation of China[81630052] ; Key Scientific Research Program of CAS[QYZDJ-SSW-SMC020] ; Youth Innovation Promotion Association of CAS[2017335] ; SA-SIBS Scholarship Program |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000488158400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288586]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Yuliang; Li, Yaping |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 5.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Pengcheng,Zhai, Yihui,Cai, Ying,et al. Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis[J]. ADVANCED MATERIALS,2019:18. |
| APA | Zhang, Pengcheng,Zhai, Yihui,Cai, Ying,Zhao, Yuliang,&Li, Yaping.(2019).Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis.ADVANCED MATERIALS,18. |
| MLA | Zhang, Pengcheng,et al."Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis".ADVANCED MATERIALS (2019):18. |
入库方式： OAI收割
来源：上海药物研究所
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