Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells
文献类型：期刊论文
| 作者 | Yang, Qian-Hao2; Jiang, Cheng-Shi3; Jin, Tao2; Xu, Jin-Fang2; Qu, Ting-Li2; Guo, Yue-Wei1 ; Zhao, Zheng-Bao2
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2018-11-02 |
| 卷号 | 20期号:11页码:1064-1074 |
| 关键词 | Tetrandrine derivatives non-small cell lung carcinoma NSCLC A549 cells anticancer activities Suzuki-Miyaura reaction |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2018.1478817 |
| 通讯作者 | Guo, Yue-Wei(ywguo@simm.ac.cn) ; Zhao, Zheng-Bao(zhengbao_z@sxmu.edu.cn) |
| 英文摘要 | A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki -Miyaura reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma (NSCLC) A549 cells. Interestingly, most of derivatives showed similar cytotoxicity to Tet against NSCLC A549 cells, and particularly, compounds Y5, Y6, Y9 and Y11 showed the most significant cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM. The present study is expected to contribute to the future design of more effective anticancer agents in lung cancer chemotherapy. |
| WOS关键词 | MULTIDRUG-RESISTANCE ; P-GLYCOPROTEIN ; BISBENZYLISOQUINOLINE ALKALOIDS ; CANCER ; APOPTOSIS ; REVERSAL |
| 资助项目 | National Nature Science Foundation of China[31700306] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000458315000007 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288591]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Yue-Wei; Zhao, Zheng-Bao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Shanxi, Peoples R China 3.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Qian-Hao,Jiang, Cheng-Shi,Jin, Tao,et al. Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2018,20(11):1064-1074. |
| APA | Yang, Qian-Hao.,Jiang, Cheng-Shi.,Jin, Tao.,Xu, Jin-Fang.,Qu, Ting-Li.,...&Zhao, Zheng-Bao.(2018).Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,20(11),1064-1074. |
| MLA | Yang, Qian-Hao,et al."Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 20.11(2018):1064-1074. |
入库方式： OAI收割
来源：上海药物研究所
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