Reactive Oxygen Species-Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies
文献类型：期刊论文
| 作者 | Zhao, Zhihao2; Wang, Weiqi3; Li, Chenxi2; Zhang, Yiqiu2; Yu, Tianrong2; Wu, Renfei2; Zhao, Jiayue2; Liu, Zhuang2; Liu, Jian2; Yu, Haijun1,4
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2019-08-29 |
| 页码 | 11 |
| 关键词 | chemodynamic therapy Fenton reaction photodynamic therapy tumor hypoxia tumor microenvironment |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201905013 |
| 通讯作者 | Liu, Jian(jliu@suda.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Tumors have adapted various cellular antidotes and microenvironmental conditions to subsist against photodynamic therapy (PDT) and chemodynamic therapy (CDT). Here, the development of reactive oxygen species (ROS)-activatable liposomes (RALP) for therapeutic enhancement by simultaneously addressing the critical questions in PDT and CDT is reported. The design of RALP@HOC@Fe3O4 features ROS-cleavable linker molecules for improved tumor penetration/uptake and ondemand cargo releasing, and integration of Fe3O4 and an oxaliplatin prodrug for smart regulation of hypoxia tumor microenvironment. Glutathione stored by the tumor cells is consumed by the prodrug to produce highly toxic oxaliplatin. Depletion of glutathione not only avoids the undesired annihilation of ROS in PDT, but also modulates the chemical specie equilibria in tumors for H2O2 promotion, leading to greatly relieved tumor hypoxia and PDT enhancement. Synergistically, Fe (II) in the hybrid RALP formulation can be fuelled by H2O2 to generate center dot OH in the Fenton reaction, thus elevating CDT efficiency. This work offers a strategy for harnessing smart, responsive, and biocompatible liposomes to enhance PDT and CDT by regulating tumor microenvironment, highlighting a potential clinical translation beneficial to patients with cancer. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; NANOPARTICLES ; CANCER ; PRODRUG ; CHEMOTHERAPY ; MECHANISMS ; GENERATION ; EFFICIENT ; ROS |
| 资助项目 | National Key Research and Development Program of China[2017YFE0131700] ; National Natural Science Foundation of China[21575095] ; National Natural Science Foundation of China[21874096] ; National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[31671024] ; Collaborative Innovation Center of Suzhou Nano Science and Technology (the 111 Project, PAPD) ; Joint International Research Laboratory of Carbon-Based Materials and Devices |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000484611700001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288605]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Jian; Yu, Haijun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China 3.Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Zhihao,Wang, Weiqi,Li, Chenxi,et al. Reactive Oxygen Species-Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies[J]. ADVANCED FUNCTIONAL MATERIALS,2019:11. |
| APA | Zhao, Zhihao.,Wang, Weiqi.,Li, Chenxi.,Zhang, Yiqiu.,Yu, Tianrong.,...&Yu, Haijun.(2019).Reactive Oxygen Species-Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies.ADVANCED FUNCTIONAL MATERIALS,11. |
| MLA | Zhao, Zhihao,et al."Reactive Oxygen Species-Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies".ADVANCED FUNCTIONAL MATERIALS (2019):11. |
入库方式： OAI收割
来源：上海药物研究所
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