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Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis

文献类型：期刊论文

作者Gong, Xiang1,2,3; Li, Jie1,2; Tan, Tao1,2; Wang, Zhiwan1,2,3; Wang, Hong1,2,3; Wang, Yuqi1,2; Xu, Xiaoxuan1,2; Zhang, Zhiwen1,2,3,4; Li, Yaping1,2,3,4
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2019-09-08
页码36
ISSN号1616-301X
关键词cancer metastasis cell membranes nanosystems tumor targeting
DOI10.1002/adfm.201903441
通讯作者Zhang, Zhiwen(zwzhang0125@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Cancer metastasis accounts for the high mortality of cancer-related deaths and the therapy is greatly challenged by the limited drug delivery efficiency. Inspired by the essential role of culprit cancer cells and versatile accessory cells during cancer metastasis, diverse cell-based nanosystems (CBNs) are emerging as attractive and encouraging drug delivery platforms to target cancer metastasis. Herein, the authors focus on the emerging strategies of versatile CBNs that synergistically combine the merit of source cells and nanoparticles for antimetastasis therapy. CBNs are usually comprised of natural nanosized vesicles, cell membrane camouflaged nanoparticles, and bioengineered living cell vehicles. The authors discuss the rationality and advances of various CBNs in targeting different stages of cancer metastasis, including primary tumor, circulating tumor cells (CTCs), and distant metastasis as well as the tumor immune microenvironments (TIM). On this basis, this review provides some feasible perspectives on designing CBNs to enhance the drug delivery efficiency for treating cancer metastasis.
WOS关键词MESENCHYMAL STEM-CELLS ; MEMBRANE-COATED NANOPARTICLES ; CIRCULATING TUMOR-CELLS ; NATURAL-KILLER-CELLS ; DRUG-DELIVERY ; LUNG METASTASIS ; T-CELLS ; INFLAMMATORY MONOCYTES ; BIOMIMETIC NANOPARTICLES ; POLYMERIC NANOPARTICLES
资助项目National Basic Research Program of China[2015CB932103] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000485588000001
源URL[http://119.78.100.183/handle/2S10ELR8/288624]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Gong, Xiang,Li, Jie,Tan, Tao,et al. Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis[J]. ADVANCED FUNCTIONAL MATERIALS,2019:36.
APA Gong, Xiang.,Li, Jie.,Tan, Tao.,Wang, Zhiwan.,Wang, Hong.,...&Li, Yaping.(2019).Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis.ADVANCED FUNCTIONAL MATERIALS,36.
MLA Gong, Xiang,et al."Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis".ADVANCED FUNCTIONAL MATERIALS (2019):36.

入库方式： OAI收割

来源：上海药物研究所

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