3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging
文献类型：期刊论文
| 作者 | Shi, Shupeng2,3; Zhang, Haoran2,3; Yin, Xianzhen4; Wang, Zhuolu1; Tang, Bin2,3; Luo, Yuebei2,3; Ding, Hui2,3; Chen, Zhuohui2,3; Cao, Yong5; Wang, Tiantian2,3 |
| 刊名 | JOURNAL OF SYNCHROTRON RADIATION
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 26页码:1742-1750 |
| 关键词 | high resolution mouse brain angioarchitecture propagation phase-contrast imaging |
| ISSN号 | 0909-0495 |
| DOI | 10.1107/S160057751900674X |
| 通讯作者 | Zhang, Mengqi(zhangmengqi8912@163.com) |
| 英文摘要 | Thorough investigation of the three-dimensional (3D) configuration of the vasculature of mouse brain remains technologically difficult because of its complex anatomical structure. In this study, a systematic analysis is developed to visualize the 3D angioarchitecture of mouse brain at ultrahigh resolution using synchrotron-radiation-based propagation phase-contrast imaging. This method provides detailed restoration of the intricate brain microvascular network in a precise 3D manner. In addition to depicting the delicate 3D arrangements of the vascular network, 3D virtual micro-endoscopy is also innovatively performed to visualize randomly a selected vessel within the brain for both external 3D micro-imaging and endoscopic visualization of any targeted microvessels, which improves the understanding of the intrinsic properties of the mouse brain angioarchitecture. Based on these data, hierarchical visualization has been established and a systematic assessment on the 3D configuration of the mouse brain microvascular network has been achieved at high resolution which will aid in advancing the understanding of the role of vasculature in the perspective of structure and function in depth. This holds great promise for wider application in various models of neurovascular diseases. |
| WOS关键词 | TOMOGRAPHY ; MICROVASCULATURE ; MICROSTRUCTURE ; VISUALIZATION ; MICROVESSELS ; NETWORK ; POINT ; LIGHT |
| 资助项目 | National Natural Science Foundation of China[81501025] ; National Natural Science Foundation of China[81601094] ; Natural Science Foundation of Hunan Province[2016JJ3174] ; Science Foundation of Xiangya Hospital for Young Scholar[2017Q01] |
| WOS研究方向 | Instruments & Instrumentation ; Optics ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000484666200040 |
| 出版者 | INT UNION CRYSTALLOGRAPHY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288686]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Mengqi |
| 作者单位 | 1.Hunan Prov Maternal & Child Hlth Care Hosp, Dept Breast Surg, Changsha 410008, Hunan, Peoples R China 2.Cent S Univ, Xiangya Hosp, Dept Neurol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China 3.Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 5.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha 410008, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Shupeng,Zhang, Haoran,Yin, Xianzhen,et al. 3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging[J]. JOURNAL OF SYNCHROTRON RADIATION,2019,26:1742-1750. |
| APA | Shi, Shupeng.,Zhang, Haoran.,Yin, Xianzhen.,Wang, Zhuolu.,Tang, Bin.,...&Zhang, Mengqi.(2019).3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging.JOURNAL OF SYNCHROTRON RADIATION,26,1742-1750. |
| MLA | Shi, Shupeng,et al."3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging".JOURNAL OF SYNCHROTRON RADIATION 26(2019):1742-1750. |
入库方式： OAI收割
来源：上海药物研究所
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