Palladium-Catalyzed Selective Synthesis of Dibenzo[c,e]azepin-5-ols and Benzo[c]pyrido[2,3-e]azepin-5-ols
文献类型：期刊论文
| 作者 | Yao, Xinrong2; Shao, Yinlin2; Hu, Maolin2; Zhang, Maosheng2; Li, Shaotong1; Xia, Yuanzhi2; Cheng, Tianxing2; Chen, Jiuxi2 |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2019-08-27 |
| 页码 | 8 |
| 关键词 | palladium-catalyzed tandem reaction dibenzo[c e]azepin-5-ols benzo[c]pyrido[2 3-e]azepin-5-ols nitriles |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201900705 |
| 通讯作者 | Chen, Jiuxi(jiuxichen@wzu.edu.cn) |
| 英文摘要 | An efficient palladium-catalyzed tandem addition/cyclization of 2 '-formyl-[1,1 '-biaryl]-2-carbonitriles with arylboronic acids is reported. This reaction affords dibenzo[c,e]azepin-5-ols and benzo[c]pyrido[2,3-e]azepin-5-ols with excellent selectivity and wide functional group compatibility. The dibenzo[c,e]azepin-5-ols show good cell growth inhibitory activity against a triple-negative breast cancer cell line. Moreover, the proposed mechanistic rationale for this tandem process is supported by theoretical calculations. |
| WOS关键词 | ARYLBORONIC ACIDS ; ARYL KETONES ; BIOLOGICAL EVALUATION ; EFFICIENT SYNTHESIS ; TANDEM REACTION ; NITRILES ; CARBOPALLADATION ; INHIBITOR ; KETIMINES ; RHODIUM |
| 资助项目 | NSFC[21572162] ; Natural Science Foundation of Zhejiang Province[LY16B020012] ; Natural Science Foundation of Zhejiang Province[LQ18B020006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000483870100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288692]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Jiuxi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Xinrong,Shao, Yinlin,Hu, Maolin,et al. Palladium-Catalyzed Selective Synthesis of Dibenzo[c,e]azepin-5-ols and Benzo[c]pyrido[2,3-e]azepin-5-ols[J]. ADVANCED SYNTHESIS & CATALYSIS,2019:8. |
| APA | Yao, Xinrong.,Shao, Yinlin.,Hu, Maolin.,Zhang, Maosheng.,Li, Shaotong.,...&Chen, Jiuxi.(2019).Palladium-Catalyzed Selective Synthesis of Dibenzo[c,e]azepin-5-ols and Benzo[c]pyrido[2,3-e]azepin-5-ols.ADVANCED SYNTHESIS & CATALYSIS,8. |
| MLA | Yao, Xinrong,et al."Palladium-Catalyzed Selective Synthesis of Dibenzo[c,e]azepin-5-ols and Benzo[c]pyrido[2,3-e]azepin-5-ols".ADVANCED SYNTHESIS & CATALYSIS (2019):8. |
入库方式： OAI收割
来源：上海药物研究所
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