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Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy

文献类型：期刊论文

作者Gao, Ang2,3,4; Hu, Xian-li1; Saeed, Madiha3,4; Chen, Bin-fan3,4; Li, Ya-ping3,4,5; Yu, Hai-jun3,4,5
刊名ACTA PHARMACOLOGICA SINICA
出版日期2019-09-01
卷号40期号:9页码:1129-1137
关键词immunotherapy liposomal NPs dendritic cells T cells tumor cells natural killer cells macrophages nanomedicine
ISSN号1671-4083
DOI10.1038/s41401-019-0281-1
通讯作者Yu, Hai-jun(hjyu@simm.ac.cn)
英文摘要The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy, and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly responsible for cancer-caused mortalities. The cancer immunotherapy is being emerged nowadays as a promising therapeutic modality in order to achieve a highly efficient therapeutic performance while circumventing tumor metastasis and relapse. Liposomal nanoparticles (NPs) may serve as an ideal platform for systemic delivery of the immune modulators. In this review, we summarize the cutting-edge progresses in liposomal NPs for cancer immunotherapy, with focus on dendritic cells, T cells, tumor cells, natural killer cells, and macrophages. The review highlights the major challenges and provides a perspective regarding the clinical translation of liposomal nanoparticle-based immunotherapy.
WOS关键词IMMUNOGENIC CELL-DEATH ; TUMOR-ASSOCIATED MACROPHAGES ; SYNTHETIC LONG PEPTIDE ; NATURAL-KILLER-CELLS ; CATIONIC LIPOSOMES ; ADVANCED MELANOMA ; DENDRITIC CELLS ; T-CELLS ; RESISTANCE ; INDUCTION
资助项目National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; CAS President's International Fellowship Initiative Program[2019PB0023]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000484000100001
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/288748]  
专题新药研究国家重点实验室
通讯作者Yu, Hai-jun
作者单位1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
2.Jiangsu Univ, Sch Pharmaceut Sci, Zhenjiang 212013, Jiangsu, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Ang,Hu, Xian-li,Saeed, Madiha,et al. Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy[J]. ACTA PHARMACOLOGICA SINICA,2019,40(9):1129-1137.
APA Gao, Ang,Hu, Xian-li,Saeed, Madiha,Chen, Bin-fan,Li, Ya-ping,&Yu, Hai-jun.(2019).Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy.ACTA PHARMACOLOGICA SINICA,40(9),1129-1137.
MLA Gao, Ang,et al."Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy".ACTA PHARMACOLOGICA SINICA 40.9(2019):1129-1137.

入库方式： OAI收割

来源：上海药物研究所

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