Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens
文献类型：期刊论文
| 作者 | Gao, Xin-Hua2; Fan, Yao-Yue2; Liu, Qun-Fang2 ; Cho, Sang-Hyun1; Pauli, Guido F.1; Chen, Shao-Nong1; Yue, Jian-Min2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-09-06 |
| 卷号 | 21期号:17页码:7065-7068 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b02630 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | The suadimins A-C (1-3) from Melodinus suaveolens are the first example of monoterpenoid quinoline alkaloid dimers featuring an unprecedented carbon skeleton. Their structures and absolute configurations were established on the basis of extensive spectroscopic analyses, electric circular dichroism (ECD), and X-ray crystallography. Suadimin A showed significant antimycobacterial activity in vitro with an MIC90 of 6.76 mu M against the H(37)Rv strain of M. tuberculosis. |
| WOS关键词 | CYTOTOXIC INDOLE ALKALOIDS ; BISINDOLE ALKALOIDS ; NATURAL-PRODUCTS ; CRYSTALLOGRAPHY |
| 资助项目 | National Natural Science Foundation of China[81861138045] ; National Natural Science Foundation of China[21532007] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Biological Resources Program, CAS of China[KFJ-BRP-008] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000485089300096 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288768]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Univ Illinois, Coll Pharm, Inst TB Res, 833 South Wood St, Chicago, IL 60612 USA 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xin-Hua,Fan, Yao-Yue,Liu, Qun-Fang,et al. Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens[J]. ORGANIC LETTERS,2019,21(17):7065-7068. |
| APA | Gao, Xin-Hua.,Fan, Yao-Yue.,Liu, Qun-Fang.,Cho, Sang-Hyun.,Pauli, Guido F..,...&Yue, Jian-Min.(2019).Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens.ORGANIC LETTERS,21(17),7065-7068. |
| MLA | Gao, Xin-Hua,et al."Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens".ORGANIC LETTERS 21.17(2019):7065-7068. |
入库方式： OAI收割
来源：上海药物研究所
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