Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods
文献类型：期刊论文
| 作者 | Gu, Sihao2; Li, Ling2; Huang, Hai1; Wang, Bing2,3; Zhang, Tong2 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 24期号:16页码:14 |
| 关键词 | Atractylodes macrocephala Koidz essential oils atractylone processing methods GC MS pharmacodynamic effect |
| DOI | 10.3390/molecules24162956 |
| 通讯作者 | Wang, Bing(bwang@simm.ac.cn) ; Zhang, Tong(zhangtdmj@hotmail.com) |
| 英文摘要 | Atractylodes macrocephala Koidz. has been used as an invigorating spleen drug for eliminating dampness and phlegm in China. According to recent researches, different processing methods may affect the drug efficacy, so we collected A. macrocephala from the Zhejiang Province, produced with different processing methods, crude A. macrocephala (CA) and bran-processed A. macrocephala (BA), then analyzed its essential oils (EOs) by GC/MS. The results showed 34 components representing 98.44% of the total EOs of CA were identified, and 46 components representing 98.02% of the total EOs of BA were identified. Atractylone is the main component in A. macrocephala. Compared with CA, BA has 46 detected compounds, 28 of which were identical, and 6 undetected compounds. Pharmacodynamic results revealed that the EOs of CA and atractylone exhibited more effective anticancer activity in HepG2, MCG803, and HCT-116 cells than the EOs of BA; while the EOs of BA exhibited simple antiviral effect on viruses H3N2, both the EOs and atractylone show anti-inflammatory activity by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in ANA-1 cells. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; CHEMICAL-COMPOSITION ; ATRACTYLENOLIDE-I ; VOLATILE COMPOUNDS ; TIGHT JUNCTIONS ; EXTRACTION ; PHASE ; CONSTITUENTS ; COMPONENTS ; RHIZOMA |
| 资助项目 | National Natural Science Foundation of China[2017ZX09201010-014-014] ; Shanghai China Medicine Development Three-Year Action Plan[ZY3-CCXX-3-4001] ; Foundation of the Shanghai Science and Technology Commission[17401902300] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000482998900009 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288779]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Bing; Zhang, Tong |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Expt Teaching Ctr Pharmaceut Sci, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Expt Ctr Teaching & Learning, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, Ctr Pharmaceut Res, 501 Hai Ke Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Sihao,Li, Ling,Huang, Hai,et al. Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods[J]. MOLECULES,2019,24(16):14. |
| APA | Gu, Sihao,Li, Ling,Huang, Hai,Wang, Bing,&Zhang, Tong.(2019).Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods.MOLECULES,24(16),14. |
| MLA | Gu, Sihao,et al."Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods".MOLECULES 24.16(2019):14. |
入库方式： OAI收割
来源：上海药物研究所
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