Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules
文献类型：期刊论文
| 作者 | Miao, William G.2; Tang, Chunping1 ; Ye, Yang1; Quinn, Ronald J.2; Feng, Yunjiang2
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 17期号:9页码:713-720 |
| 关键词 | Extraction Traditional Chinese medicine (TCM) Natural products Lipinski's Ro5Physicochemical properties |
| ISSN号 | 2095-6975 |
| 通讯作者 | Quinn, Ronald J.(r.quinn@griffith.edu.au) ; Feng, Yunjiang(y.feng@griffith.edu.au) |
| 英文摘要 | Traditional Chinese Medicine (TCM) is an important reservoir for bioactive natural products. TCM extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged efficacy. In this study, we selected 6 common TCMs that are rich in chemistry to investigate whether the TCM extraction methods deliver molecules with drug-like physical chemical properties. Six TCM herbal materials were extracted by water, 95% ethanol, and sequential hexane, dichloromethane and methanol. The extracts were analyzed by HPLC and H-1 NMR. Isolation on one of the extracts yielded 32 compounds, their physical chemical properties were analyzed by Instant JChem. Our results showed that ethanol extraction, which mimics TCM wine tincture, delivered compounds with physical chemical properties compliant to Lipinski's rule of 5. |
| WOS关键词 | PHENOLIC-COMPOUNDS ; HERBAL MEDICINES ; GASTRODIA-ELATA ; CONSTITUENTS ; DISCOVERY ; INHIBITION ; PRINCIPLES ; RHIZOMES |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000485870100009 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288805]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Quinn, Ronald J.; Feng, Yunjiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Griffith Univ, Griffith Inst Drug Discovery GRIDD, Nathan, Qld 4111, Australia |
| 推荐引用方式 GB/T 7714 | Miao, William G.,Tang, Chunping,Ye, Yang,et al. Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(9):713-720. |
| APA | Miao, William G.,Tang, Chunping,Ye, Yang,Quinn, Ronald J.,&Feng, Yunjiang.(2019).Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules.CHINESE JOURNAL OF NATURAL MEDICINES,17(9),713-720. |
| MLA | Miao, William G.,et al."Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules".CHINESE JOURNAL OF NATURAL MEDICINES 17.9(2019):713-720. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。