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Integrating yeast chemical genomics and mammalian cell pathway analysis

文献类型：期刊论文

作者Zhou, Fu-lai2,3,4; Li, Sheena C.5; Zhu, Yue2,3,4; Guo, Wan-jing2,3,4; Shao, Li-jun2,3,4; Nelson, Justin1; Simpkins, Scott1; Yang, De-hua2,3; Liu, Qing2,3; Yashiroda, Yoko5
刊名ACTA PHARMACOLOGICA SINICA
出版日期2019-09-01
卷号40期号:9页码:1245-1255
ISSN号1671-4083
关键词yeast chemical genomics tubulin cytoskeleton assembly autophagy Wnt/beta-catenin signaling pathway
DOI10.1038/s41401-019-0231-y
通讯作者Myers, Chad L.(chadm@umn.edu) ; Boone, Charles(charlie.boone@utoronto.ca) ; Wang, Ming-wei(mwwang@simm.ac.cn)
英文摘要Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large-scale chemical-genetic profiling of thousands of synthetic and natural compounds from the Chinese National Compound Library identified those with high-confidence bioprocess target predictions. To discover compounds that have the potential to function like therapeutic agents with known targets, we also analyzed a reference library of approved drugs. Previously uncharacterized compounds with chemical-genetic profiles resembling existing drugs that modulate autophagy and Wnt/beta-catenin signal transduction were further examined in mammalian cells, and new modulators with specific modes of action were validated. This analysis exploits yeast as a general platform for predicting compound bioactivity in mammalian cells.
WOS关键词MONITORING AUTOPHAGY ; DNA-DAMAGE ; DISEASE ; CATENIN ; TARGET ; MODEL ; EXPLORATION ; ALKALOIDS ; COMPLEX ; TRANSCRIPTION
资助项目Shanghai Municipality Science and Technology Development Fund[18430711500] ; JSPS[17H06411] ; RIKEN Foreign Postdoctoral Research Fellowship ; National Natural Science Foundation of China[61571202]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000484000100012
源URL[http://119.78.100.183/handle/2S10ELR8/288818]  
专题新药研究国家重点实验室
通讯作者Myers, Chad L.; Boone, Charles; Wang, Ming-wei
作者单位1.Univ Minnesota Twin Cities, Bioinformat & Computat Biol Program, Minneapolis, MN 55455 USA
2.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.RIKEN Ctr Sustainable Resource Sci, Wako, Saitama 3510198, Japan
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
7.Univ Tokyo, Dept Biol, Bunkyo Ku, Tokyo 1138657, Japan
8.Univ Tokyo, Collaborat Res Innovat Microbiol, Bunkyo Ku, Tokyo 1138657, Japan
9.Huazhong Univ Sci & Technol, Dept Elect & Informat Engn, Wuhan 430074, Hubei, Peoples R China
10.Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada
推荐引用方式
GB/T 7714		 Zhou, Fu-lai,Li, Sheena C.,Zhu, Yue,et al. Integrating yeast chemical genomics and mammalian cell pathway analysis[J]. ACTA PHARMACOLOGICA SINICA,2019,40(9):1245-1255.
APA Zhou, Fu-lai.,Li, Sheena C..,Zhu, Yue.,Guo, Wan-jing.,Shao, Li-jun.,...&Wang, Ming-wei.(2019).Integrating yeast chemical genomics and mammalian cell pathway analysis.ACTA PHARMACOLOGICA SINICA,40(9),1245-1255.
MLA Zhou, Fu-lai,et al."Integrating yeast chemical genomics and mammalian cell pathway analysis".ACTA PHARMACOLOGICA SINICA 40.9(2019):1245-1255.

入库方式： OAI收割

来源：上海药物研究所

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