Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases
文献类型：期刊论文
| 作者 | Yon, Kai-Cheng2,3; Sedgwick, Adam C.4; Zang, Yi5 ; Chen, Guo-Rong2,3; He, Xiao-Peng2,3; Li, Jia5; Yoon, Juyoung1; James, Tony D.6
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| 刊名 | SMALL METHODS
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| 出版日期 | 2019-07-10 |
| 卷号 | 3期号:7页码:42 |
| 关键词 | fluorescence imaging agents ROS sensors theranostics |
| ISSN号 | 2366-9608 |
| DOI | 10.1002/smtd.201900013 |
| 通讯作者 | He, Xiao-Peng(xphe@ecust.edu.cn) ; Li, Jia(jli@simm.ac.cn) ; Yoon, Juyoung(jyoon@wha.ac.kr) ; James, Tony D.(t.d.james@bath.ac.uk) |
| 英文摘要 | Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence-based strategies, many small-molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence-based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed. |
| WOS关键词 | 2-PHOTON FLUORESCENT-PROBE ; RESPONSIVE DRUG-DELIVERY ; ENDOGENOUS HYDROXYL RADICALS ; AMINOFERROCENE-BASED PRODRUGS ; LIGHT-ACTIVATABLE PRODRUG ; THIOLS REDUCING REPAIR ; H2O2 OXIDATIVE STRESS ; TRACE VAPOR DETECTION ; HYDROGEN-PEROXIDE ; HYPOCHLOROUS ACID |
| 资助项目 | National Natural Science Foundation of China[91853201] ; National Natural Science Foundation of China[21722801] ; National Natural Science Foundation of China[21776078] ; National Natural Science Foundation of China[81673489] ; National Natural Science Foundation of China[81125023] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; K. C. Wong Education Foundation ; Fundamental Research Funds for the Central Universities[222201717003] ; Royal Society ; National Research Foundation of Korea (NRF) - Korea government (MSIP)[2012R1A3A2048814] ; [16430724100] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000479005000002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288882]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | He, Xiao-Peng; Li, Jia; Yoon, Juyoung; James, Tony D. |
| 作者单位 | 1.Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea 2.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA 5.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 6.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England |
| 推荐引用方式 GB/T 7714 | Yon, Kai-Cheng,Sedgwick, Adam C.,Zang, Yi,et al. Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases[J]. SMALL METHODS,2019,3(7):42. |
| APA | Yon, Kai-Cheng.,Sedgwick, Adam C..,Zang, Yi.,Chen, Guo-Rong.,He, Xiao-Peng.,...&James, Tony D..(2019).Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases.SMALL METHODS,3(7),42. |
| MLA | Yon, Kai-Cheng,et al."Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases".SMALL METHODS 3.7(2019):42. |
入库方式： OAI收割
来源：上海药物研究所
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