Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes
文献类型：期刊论文
| 作者 | Sun, Peng1,2; Li, Kai2; Wang, Ting1; Ji, Jun1; Wang, Yan2; Chen, Kai-Xian1,3 ; Jia, Qi3; Li, Yi-Ming3; Wang, He-Yao1
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2019-08-14 |
| 卷号 | 67期号:32页码:8839-8846 |
| ISSN号 | 0021-8561 |
| 关键词 | cinnamon extracts B-type procyanidin 3T3-L1 adipocytes insulin sensitivity glucose uptake |
| DOI | 10.1021/acs.jafc.9b02932 |
| 通讯作者 | Li, Yi-Ming(ymlius@163.com) ; Wang, He-Yao(hywang@simm.ac.cn) |
| 英文摘要 | Natural products are one of the main sources for discovering new lead compounds. We previously reported that cinnamon extract has a promising effect in regulating lipid tissue volume and insulin sensitivity in vivo. However, its effective component and the underlying mechanism are not known. In the present study, we analyzed the effect of different components of cinnamon on regulating insulin sensitivity in 3T3-L1 adipocytes. Functional assay revealed that, of the six major components of cinnamon extracts, the B-type procyanidin, procyanidin C1, improves the differentiation of 3T3-L1 cells (TG content: 1.10 +/- 0.09 mM at a dosage of 25 mu M vs 0.67 +/- 0.02 mM in vehicle group, p < 0.001) and promotes insulin-induced glucose uptake (8.58 +/- 1.43 at a dosage of 25 mu M vs 3.05 +/- 1.24 in vehicle group, p < 0.001). Mechanism studies further suggested that procyanidin C1 activates the AKT-eNOS pathway, thus up-regulating glucose uptake and enhancing insulin sensitivity in mature adipocytes. Taken together, our study identified B-type procyanidin C1, a component of cinnamon extract, that stimulates preadipocyte differentiation and acts as a potential insulin action enhancer through the AKT-eNOS pathway in mature adipocytes. |
| WOS关键词 | PANCREATIC BETA-CELLS ; SUBCUTANEOUS ADIPOSE-TISSUE ; NITRIC-OXIDE ; GLUCOSE-UPTAKE ; DIFFERENTIATION ; TRIMER ; ACTIVATION ; ADIPOGENESIS ; PATHWAY ; PROTEIN |
| 资助项目 | National Natural Science Foundation of China[81773791] ; National Natural Science Foundation of China[81473262] ; National Natural Science Foundation of China[81603169] ; National Natural Science Foundation of China[81600598] ; Personalized Medicines-Molecular Signature -based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040336] ; Natural Science Foundation of Jiangsu Province[BK20161027] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-002-007] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000481563600013 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288904]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yi-Ming; Wang, He-Yao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Nanjing Med Univ, Key Lab Human Funct Genom Jiangsu Prov, Nanjing 211166, Jiangsu, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Peng,Li, Kai,Wang, Ting,et al. Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(32):8839-8846. |
| APA | Sun, Peng.,Li, Kai.,Wang, Ting.,Ji, Jun.,Wang, Yan.,...&Wang, He-Yao.(2019).Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(32),8839-8846. |
| MLA | Sun, Peng,et al."Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.32(2019):8839-8846. |
入库方式： OAI收割
来源：上海药物研究所
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