Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins
文献类型：期刊论文
| 作者 | Xue, Dongxiang1,2,3,4; Xu, Tiandan1,3,4,5; Wang, Huixia1,3,4,5; Wu, Meng1,3,4,5; Yuan, Ya1; Wang, Wei6; Tan, Qiwen1; Zhao, Fei1; Zhou, Fang1,2,3,4; Hu, Tao1,3,4,5 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2019-08-13 |
| 页码 | 7 |
| 关键词 | detergents disulfides membrane proteins micelle size NMR spectroscopy |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201903190 |
| 通讯作者 | Wuthrich, Kurt(wuthrich@scripps.edu) ; Tao, Houchao(taohch@shanghaitech.edu.cn) |
| 英文摘要 | Disulfide-containing detergents (DCDs) are introduced, which contain a disulfide bond in the hydrophobic tail. DCDs form smaller micelles than corresponding detergents with linear hydrocarbon chains, while providing good solubilization and reconstitution of membrane proteins. The use of this new class of detergents in structural biology is illustrated with solution NMR spectra of the human G protein-coupled receptor A(2A)AR, which is an alpha-helical protein, and the beta-barrel protein OmpX from E. coli. |
| WOS关键词 | CRYSTAL-STRUCTURE ; RECEPTOR ; NMR ; AMPHIPHILES ; STABILITY ; MICELLES ; COMPLEX ; ACIDS ; BILE |
| 资助项目 | National Natural Science Foundation of China[21672147] ; National Natural Science Foundation of China[31670733] ; Shanghai Municipal Government, ShanghaiTech University |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000481113100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288921]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wuthrich, Kurt; Tao, Houchao |
| 作者单位 | 1.ShanghaiTech Univ, iHuman Inst, Ren Bldg,393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 6.Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Dongxiang,Xu, Tiandan,Wang, Huixia,et al. Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019:7. |
| APA | Xue, Dongxiang.,Xu, Tiandan.,Wang, Huixia.,Wu, Meng.,Yuan, Ya.,...&Tao, Houchao.(2019).Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.CHEMISTRY-A EUROPEAN JOURNAL,7. |
| MLA | Xue, Dongxiang,et al."Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins".CHEMISTRY-A EUROPEAN JOURNAL (2019):7. |
入库方式： OAI收割
来源：上海药物研究所
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