Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy
文献类型：期刊论文
| 作者 | Feng, Bing1,2,3; Hou, Bo1,2,4; Xu, Zhiai4; Saeed, Madiha1,2; Yu, Haijun1,2,3 ; Li, Yaping1,2,3
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| 刊名 | ADVANCED MATERIALS
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| 出版日期 | 2019-08-18 |
| 页码 | 10 |
| 关键词 | cancer metastasis chemoimmunotherapy immunogenic cell death immunosuppressive tumor microenvironment self-amplification |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201902960 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn) |
| 英文摘要 | Chemoimmunotherapy by systemic administration of individual regimens suffers from inconsistent pharmacokinetics profiles, low tumor specificity, and severe side effects. Despite promising nanoparticle-based codelivery approaches in therapeutics, the pathophysiological barriers of solid tumors are a hurdle for tumor accumulation and deep penetration of the drug-loaded nanoparticles. A light-inducible nanocargo (LINC) for immunotherapy is reported. LINC is composed of a reduction-responsive heterodimer of photosensitizer pheophorbide A (PPa) and indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, i.e., NLG919, and a light-activatable prodrug of oxaliplatin (OXA). LINC administrated through intravenous injection is passively accumulated at the tumor site to generate near-infrared (NIR) fluorescence signal. Under fluorescence imaging guidance, the first-wave of NIR laser irradiation induce reactive oxygen species (ROS) generation, trigger cleavage of the polyethylene glycol (PEG) corona, and thus promote tumor retention and deep penetration of LINC. When exposed to the second-wave NIR laser illumination, LINC efficiently elicits the immune response and promotes intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Furthermore, NLG919 delivered by LINC reverses the immunosuppressive tumor microenvironment by suppressing IDO-1 activity. Chemoimmunotherapy with LINC inhibit the tumor growth, lung metastasis, and tumor recurrence. The light-inducible self-amplification strategy for improved drug delivery and immunotherapy shows potential. |
| WOS关键词 | IMMUNE CHECKPOINT BLOCKADE ; IMMUNOGENIC CELL-DEATH ; PHOTODYNAMIC THERAPY ; NANOPARTICLES ; OPPORTUNITIES ; INHIBITION ; IDO1 |
| 资助项目 | National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000481820600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288978]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Bing,Hou, Bo,Xu, Zhiai,et al. Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy[J]. ADVANCED MATERIALS,2019:10. |
| APA | Feng, Bing,Hou, Bo,Xu, Zhiai,Saeed, Madiha,Yu, Haijun,&Li, Yaping.(2019).Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy.ADVANCED MATERIALS,10. |
| MLA | Feng, Bing,et al."Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy".ADVANCED MATERIALS (2019):10. |
入库方式： OAI收割
来源：上海药物研究所
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