In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride
文献类型：期刊论文
| 作者 | Liang, Xiao1; Chen, Yulin1; Wu, Li2; Maharjan, Abi2; Regmi, Balmukunda5; Zhang, Jiwen2 ; Gui, Shuangying1,3,4
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| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
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| 出版日期 | 2019-09-01 |
| 卷号 | 117页码:8 |
| 关键词 | In Situ hexagonal liquid crystal Sinomenine hydrochloride Rheumatoid arthritis Sustained release Intra-articular administration |
| ISSN号 | 0753-3322 |
| DOI | 10.1016/j.biopha.2019.108993 |
| 通讯作者 | Gui, Shuangying(guishy0520@126.com) |
| 英文摘要 | The aim of this study was to investigate the release behaviors of sinomenine hydrochloride loaded via in situ hexagonal liquid crystal (ISH), and its potential to improve the local bioavailability in knee joints of sinomenine hydrochloride (SMH) after intra-articular administration. The ISH was prepared by a liquid precursor mixture containing phytantriol (PT), Vitamin E acetate (VEA), ethanol (ET), and water. The in vitro release profiles revealed a sustained release of SMH from the optimized ISH formula (PT/VEA/ET/water, 60.8:3.2:16.0:20.0, w/w/w/w), which was selected for the in vivo pharmacokinetics and preliminary pharmacodynamics studies. In both healthy and adjuvant-induced arthritis (AA) rats, the SMH loaded ISH showed significantly smaller SMH AUC(0-infinity) in plasma (P < 0.01), and higher SMH concentration in synoviums (2(similar to)168 h) than that of SMH solution, indicating that the ISH significantly reduced the leakage of SMH into systemic circulation. The t(1/2 alpha) of SMH loaded ISH in the knee joints of AA rats, was longer (13.42 h) than that of healthy rats (1.34 h) (P < 0.05), most likely that in vivo drug release behavior of SMH loaded ISH was affected by the physiological environment of the joint. It was found that the SMH loaded ISH could benefit AA-rats by suppressing the level of IL-1 beta in comparison to SMH solutions. The results of the histopathology of knee joints in AA rats displayed that the SMH loaded ISH might be suitable for the development of treatment strategies for rheumatoid arthritis diseases. |
| WOS关键词 | RHEUMATOID-ARTHRITIS ; CUBIC PHASE ; DRUG ; RATS ; PHARMACOKINETICS ; RELEASE ; SYSTEMS |
| 资助项目 | National Nature Science Foundation of China[81873019] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000477804500056 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289038]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gui, Shuangying |
| 作者单位 | 1.Anhui Univ Chinese Med, 1 Qianjiang St, Hefei 230012, Anhui, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Anhui Acad Chinese Med, Inst Pharmaceut, Hefei, Anhui, Peoples R China 4.Educ Off Anhui Prov, Engn Technol Res Ctr Modernized Pharmaceut, Hefei, Anhui, Peoples R China 5.Tribhuvan Univ, Kathmandu, Nepal |
| 推荐引用方式 GB/T 7714 | Liang, Xiao,Chen, Yulin,Wu, Li,et al. In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride[J]. BIOMEDICINE & PHARMACOTHERAPY,2019,117:8. |
| APA | Liang, Xiao.,Chen, Yulin.,Wu, Li.,Maharjan, Abi.,Regmi, Balmukunda.,...&Gui, Shuangying.(2019).In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride.BIOMEDICINE & PHARMACOTHERAPY,117,8. |
| MLA | Liang, Xiao,et al."In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride".BIOMEDICINE & PHARMACOTHERAPY 117(2019):8. |
入库方式： OAI收割
来源：上海药物研究所
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