Rapid structure identification of nineteen metabolites of ondansetron in human urine using LC/MSn
文献类型：期刊论文
| 作者 | Duan, Mingyu1,2,3; Qin, Li1; Zhong, Dafang4,5 ; Zhang, Peng1
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2019-07-24 |
| 页码 | 7 |
| 关键词 | human metabolism LC MSn metabolic pathways ondansetron |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.4618 |
| 通讯作者 | Zhang, Peng(zhangpengspu@163.com) |
| 英文摘要 | Ondansetron, a 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, is regarded as an excellent candidate to treat chemotherapy- and radiotherapy-induced nausea and vomiting. To better understand the metabolic profiles of ondansetron in human urine, the metabolites were analyzed using liquid chromatography/mass spectrometry (LC/MSn). Urine samples were collected after oral administration of 8 mg ondansetron to healthy volunteers. Then samples were treated by solid-phase extraction and detected with LC/MSn. Besides ondansetron, in human urine, a total of 19 metabolites including 13 new metabolites were detected and identified via comparing the retention time and product ion spectra with those of reference standards isolated and characterized. The results showed that ondansetron was metabolized via hydroxylation, glucuronidation, sulfation and minor N-demethylation in human. LC/MSn was demonstrated to be useful and sensitive in the metabolic study of ondansetron. |
| WOS关键词 | POSTOPERATIVE NAUSEA ; RECEPTOR ANTAGONISTS ; PHARMACOLOGY ; CYTOCHROME-P450 ; CHEMOTHERAPY ; EFFICACY |
| 资助项目 | National Natural Science Foundation of China[81521005] ; '863' Program of China[2003 AA2Z347C] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000478699200001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289073]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Peng |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Quarkman Pharmaceut Technol Co LTD, Bioanal Ctr, Benxi, Liaoning, Peoples R China 3.Quarkman Pharmaceut Technol Co LTD, New & High Tech Dev Zone, A1 Innovat Pk, Benxi, Liaoning, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Mingyu,Qin, Li,Zhong, Dafang,et al. Rapid structure identification of nineteen metabolites of ondansetron in human urine using LC/MSn[J]. BIOMEDICAL CHROMATOGRAPHY,2019:7. |
| APA | Duan, Mingyu,Qin, Li,Zhong, Dafang,&Zhang, Peng.(2019).Rapid structure identification of nineteen metabolites of ondansetron in human urine using LC/MSn.BIOMEDICAL CHROMATOGRAPHY,7. |
| MLA | Duan, Mingyu,et al."Rapid structure identification of nineteen metabolites of ondansetron in human urine using LC/MSn".BIOMEDICAL CHROMATOGRAPHY (2019):7. |
入库方式： OAI收割
来源：上海药物研究所
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