Non-viral gene delivery for cancer immunotherapy
文献类型：期刊论文
| 作者 | Wang, Weiqi1,2,3; Saeed, Madiha2,3; Zhou, Yao1; Yang, Lili1; Wang, Dangge2,3; Yu, Haijun2,3,4
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| 刊名 | JOURNAL OF GENE MEDICINE
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| 出版日期 | 2019-07-01 |
| 卷号 | 21期号:7页码:11 |
| 关键词 | cancer immunotherapy gene delivery nanoparticles stimuli-responsive tumor microenvironment |
| ISSN号 | 1099-498X |
| DOI | 10.1002/jgm.3092 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Recent decades have witnessed the revolutionary development of cancer immunotherapies, which boost cancer-specific immune responses for long-term tumor regression. However, immunotherapy still has limitations, including off-target side effects, long processing times and limited patient responses. These disadvantages of current immunotherapy are being addressed by improving our understanding of the immune system, as well as by establishing combinational approaches. Advanced biomaterials and gene delivery systems overcome some of these delivery issues, harnessing adverse effects and amplifying immunomodulatory effects, and are superior to standard formulations with respect to eliciting antitumor immunity. Nucleic acid-based nanostructures have diverse functions, ranging from gene expression and gene regulation to pro-inflammatory effects, as well as the ability to specifically bind different molecules. A brief overview is provided of the recent advances in the non-viral gene delivery methods that are being used to activate cancer-specific immune responses. Furthermore, the tumor microenvironment-responsive synergistic strategies that modulate the immune response by targeting various signaling pathways are discussed. Nanoparticle-based non-viral gene delivery strategies have great potential to be implemented in the clinic for cancer immunotherapy. |
| WOS关键词 | DENDRITIC CELLS ; T-CELLS ; PD-L1 BLOCKADE ; IN-VIVO ; TUMOR MICROENVIRONMENT ; ANTITUMOR IMMUNITY ; RNA DELIVERY ; LYMPH-NODE ; NANOPARTICLES ; THERAPY |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000477905900007 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289087]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun |
| 作者单位 | 1.Nantong Univ, Sch Pharm, Nantong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Weiqi,Saeed, Madiha,Zhou, Yao,et al. Non-viral gene delivery for cancer immunotherapy[J]. JOURNAL OF GENE MEDICINE,2019,21(7):11. |
| APA | Wang, Weiqi,Saeed, Madiha,Zhou, Yao,Yang, Lili,Wang, Dangge,&Yu, Haijun.(2019).Non-viral gene delivery for cancer immunotherapy.JOURNAL OF GENE MEDICINE,21(7),11. |
| MLA | Wang, Weiqi,et al."Non-viral gene delivery for cancer immunotherapy".JOURNAL OF GENE MEDICINE 21.7(2019):11. |
入库方式： OAI收割
来源：上海药物研究所
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