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Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis

文献类型：期刊论文

作者Wu, Jie-Wei1,2; Li, Bai-Lin1; Tang, Chunping2; Ke, Chang-Qang2; Zhu, Nan-Lin2; Qiu, Sheng-Xiang3; Ye, Yang2
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2019-07-01
卷号82期号:7页码:1917-1922
ISSN号0163-3864
DOI10.1021/acs.jnatprod.9b00064
通讯作者Qiu, Sheng-Xiang(sxqiu@scbg.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn)
英文摘要A phytochemical investigation on the leaves of Callistemon viminalis resulted in the isolation of two unusual compounds, callistemonols A (1) and B (2). Callistemonol A (1) possesses a novel skeleton of a furan ring fusing both an alpha,beta-triketone and a phloroglucinol unit, while callistemonol B (2) is an acylphloroglucinol derivative featuring two methyl substituents on a five-membered ring and an isovaleryl side chain. Their structures were fully characterized on the basis of extensive spectroscopic analysis, including 1D and 2D NMR parameters, as well as the IR and HRESIMS data. Callistemonol A (1) represents an example of a natural dibenzofuran with two phenyl moieties, and a plausible biogenetic pathway to generate this novel dibenzofuran through a C C bond-forming radical SAM enzyme is proposed. Moreover, antimicrobial assays, in conjunction with time-killing and biophysical studies, revealed that 1 and 2 exert potent bactericidal activities against a panel of methicillin-resistant pathogenic microbes.
WOS关键词PHLOROGLUCINOL DERIVATIVES ; ANTIBACTERIAL ACTIVITY ; LEAVES ; SPECTRUM ; ENZYMES ; OUTER
资助项目State Key Laboratory of Drug Research[SIMM1803KF-09] ; China Postdoctoral Science Foundation[2015M582436]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000477917800021
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/289117]  
专题新药研究国家重点实验室
通讯作者Qiu, Sheng-Xiang; Ye, Yang
作者单位1.Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Chem Dept, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Program Nat Prod Chem Biol,Key Lab Plant Resource, Guangzhou 510650, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Jie-Wei,Li, Bai-Lin,Tang, Chunping,et al. Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(7):1917-1922.
APA Wu, Jie-Wei.,Li, Bai-Lin.,Tang, Chunping.,Ke, Chang-Qang.,Zhu, Nan-Lin.,...&Ye, Yang.(2019).Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis.JOURNAL OF NATURAL PRODUCTS,82(7),1917-1922.
MLA Wu, Jie-Wei,et al."Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis".JOURNAL OF NATURAL PRODUCTS 82.7(2019):1917-1922.

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来源：上海药物研究所

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