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N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles

文献类型：期刊论文

作者Zhang, Zi-Jing1,2; Zhang, Ling1,2; Geng, Rui-Long1,2; Song, Jin1,2; Chen, Xiao-Hua3; Gong, Liu-Zhu1,2,4
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2019-07-24
页码6
关键词cooperative catalysis copper enals N-heterocyclic carbenes spirooxindoles
ISSN号1433-7851
DOI10.1002/anie.201907188
通讯作者Song, Jin(jill@ustc.edu.cn) ; Gong, Liu-Zhu(gonglz@ustc.edu.cn)
英文摘要Highly enantioselective [3+3] and [3+4] annulations of isatin-derived enals with ethynylethylene carbonates and ethynyl benzoxazinanones are enabled by NHC/cooper cooperative catalysis, leading to a big library of spirooxindole derivatives in high structural diversity and enantioselectivity (up to 99 % ee). Both reactions represent a nicely synergistic integration of NHC and copper catalysis, in which both catalysts activate the substrates and the chiral NHC perfectly controls the stereochemistry.
WOS关键词ISATIN-DERIVED ENALS ; ENANTIOSELECTIVE SYNTHESIS ; SYNERGISTIC CATALYSIS ; DUAL CATALYSIS ; 3+3 ANNULATION ; NHC CATALYSIS ; ACCESS ; ORGANOCATALYSIS ; ALLYLATION ; SCAFFOLDS
资助项目NSFC[21831007] ; NSFC[21702199] ; Chinese Academy of Science[XDB20000000] ; Anhui Provincial Natural Science Foundation[1808085QB30]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000478399800001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/289148]  
专题中国科学院上海药物研究所
通讯作者Song, Jin; Gong, Liu-Zhu
作者单位1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Mol Synth, Hefei 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zi-Jing,Zhang, Ling,Geng, Rui-Long,et al. N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019:6.
APA Zhang, Zi-Jing,Zhang, Ling,Geng, Rui-Long,Song, Jin,Chen, Xiao-Hua,&Gong, Liu-Zhu.(2019).N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6.
MLA Zhang, Zi-Jing,et al."N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019):6.

入库方式： OAI收割

来源：上海药物研究所

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