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Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination

文献类型：期刊论文

作者Sun, Xiaoyi1; Zeng, Linghui1; Huang, Yongzhuo2
刊名JOURNAL OF GENE MEDICINE
出版日期2019-07-01
卷号21期号:7页码:14
关键词cancer immunotherapy DNA mRNA transcutaneous delivery transcutaneous immunization vaccine
ISSN号1099-498X
DOI10.1002/jgm.3089
通讯作者Sun, Xiaoyi(sunxiaoyi@zucc.edu.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Therapeutic vaccination is a promising strategy for the immunotherapy of cancers. It eradicates cancer cells by evoking and strengthening the patient's own immune system. Because of the easy access and sophisticated immune networks, the skin becomes an ideal target organ for vaccination. Genetic vaccines have been widely investigated, with the advantages of the delivery of multiple antigens and a lower cost for production compared to protein/peptide vaccines. This review summarizes the advances made with respect to the transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination and also gives a brief description of the immunological milieu of the skin and the importance of dendritic cell-targeting in vaccine delivery, as well as the technologies that aim to facilitate antigen delivery and modulate antigen-presenting cells, thus improving cellular responses. The applications of genetic vaccines encoding tumor antigens delivered through the skin route, both in preclinical and clinical trials, are outlined.
WOS关键词GENE GUN IMMUNIZATION ; MEDIATED EPIDERMAL DELIVERY ; HEPATITIS-B-VIRUS ; DNA VACCINE ; DENDRITIC CELLS ; LANGERHANS CELLS ; PLASMID DNA ; INTRADERMAL DELIVERY ; LIPID NANOPARTICLES ; HOLLOW MICRONEEDLES
资助项目National Basic Research Program of China (973 Program)[2014CB931900] ; NFSC[814022883] ; NFSC[81422048] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009] ; Natural Science Foundation of Zhejiang[LY17H160002]
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000477905900003
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/289175]  
专题新药研究国家重点实验室
通讯作者Sun, Xiaoyi; Huang, Yongzhuo
作者单位1.Zhejiang Univ City Coll, Sch Med, 48 Huzhou St, Hangzhou 310015, Zhejiang, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Xiaoyi,Zeng, Linghui,Huang, Yongzhuo. Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination[J]. JOURNAL OF GENE MEDICINE,2019,21(7):14.
APA Sun, Xiaoyi,Zeng, Linghui,&Huang, Yongzhuo.(2019).Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination.JOURNAL OF GENE MEDICINE,21(7),14.
MLA Sun, Xiaoyi,et al."Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination".JOURNAL OF GENE MEDICINE 21.7(2019):14.

入库方式： OAI收割

来源：上海药物研究所

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