Effect of ethnicity on vinorelbine pharmacokinetics: a population pharmacokinetics analysis
文献类型：期刊论文
| 作者 | Petain, Aurelie1; Zhong, Dafang2 ; Chen, Xiaoyan2; Li, Zhang3; Shao Zhimin4; Jiang Zefei5; Zorza, Gregoire1; Ferre, Pierre1
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| 刊名 | CANCER CHEMOTHERAPY AND PHARMACOLOGY
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| 出版日期 | 2019-08-01 |
| 卷号 | 84期号:2页码:373-382 |
| 关键词 | Vinorelbine Non-small-cell lung cancer Breast cancer China Pharmacokinetics |
| ISSN号 | 0344-5704 |
| DOI | 10.1007/s00280-019-03872-9 |
| 通讯作者 | Ferre, Pierre(pierre.ferre@pierre-fabre.com) |
| 英文摘要 | BackgroundPharmacokinetics of vinorelbine is mainly known from studies conducted in European patients. Interethnic differences in drug disposition may, however, induce interethnic variation in drug exposure. This paper aimed to evaluate the effect of ethnicity on the bioavailability and clearance of oral and intravenous vinorelbine.MethodsOral and intravenous vinorelbine pharmacokinetics data in Asian patients were pooled from two-phase II studies of patients with non-small-cell lung cancer or advanced breast cancer in China. Blood vinorelbine and its active metabolite, 4-O-deacetylvinorelbine, were quantified using liquid chromatography-tandem mass spectrometry. Bayesian pharmacokinetic parameters were calculated and vinorelbine monotherapy results (intravenous 25mg/m(2); oral 60mg/m(2)) of the Asian data set were compared to a reference European data set (intravenous 30mg/m(2); oral 80mg/m(2)). Subsequently, a population pharmacokinetics analysis was conducted in a combined cohort (Asian data set+historical vinorelbine pharmacokinetics database) to investigate for a potential effect of ethnicity.ResultsPharmacokinetics data from the Asian data set (oral: n=47; intravenous: n=34) was compared to the European reference data set (oral: n=48; intravenous: n=48). Mean apparent clearance of oral vinorelbine and mean absolute clearance of intravenous vinorelbine was comparable between the Asian and reference European data set. A population pharmacokinetic analysis (oral: n=222; intravenous: n=111) demonstrated no influence of ethnicity on oral and intravenous vinorelbine bioavailability and clearance.Conclusion Vinorelbine pharmacokinetics were found to be comparable between Asian and European patients. No relevant influence of ethnicity on vinorelbine bioavailability and clearance for oral and intravenous routes of administration was observed. |
| WOS关键词 | PHASE-I ; INTRAVENOUS VINORELBINE ; CLINICAL PHARMACOKINETICS ; METABOLISM ; BLOOD ; MODEL ; RACE |
| 资助项目 | Pierre Fabre Medicament, France |
| WOS研究方向 | Oncology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000475686400016 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289194]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ferre, Pierre |
| 作者单位 | 1.Inst Rech Pierre Fabre, 3 Ave Hubert Curien, F-31035 Toulouse, France 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Sun Yat Sen Univ, Ctr Canc, Guangzhou, Guangdong, Peoples R China 4.Fudan Univ, Canc Hosp, Shanghai, Peoples R China 5.307 Hosp PLA, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Petain, Aurelie,Zhong, Dafang,Chen, Xiaoyan,et al. Effect of ethnicity on vinorelbine pharmacokinetics: a population pharmacokinetics analysis[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY,2019,84(2):373-382. |
| APA | Petain, Aurelie.,Zhong, Dafang.,Chen, Xiaoyan.,Li, Zhang.,Shao Zhimin.,...&Ferre, Pierre.(2019).Effect of ethnicity on vinorelbine pharmacokinetics: a population pharmacokinetics analysis.CANCER CHEMOTHERAPY AND PHARMACOLOGY,84(2),373-382. |
| MLA | Petain, Aurelie,et al."Effect of ethnicity on vinorelbine pharmacokinetics: a population pharmacokinetics analysis".CANCER CHEMOTHERAPY AND PHARMACOLOGY 84.2(2019):373-382. |
入库方式： OAI收割
来源：上海药物研究所
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