New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.
文献类型：期刊论文
| 作者 | Jiang, Cheng-Shi1; Ru, Tong2,3; Huan, Xia-Juan2,3; Miao, Ze-Hong2,3; Guo, Yue-Wei2,3,4
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| 刊名 | STEROIDS
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 149页码:5 |
| 关键词 | Soft coral Sinularia sp. Ergostane Antiproliferative activity Apoptosis |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2019.108425 |
| 通讯作者 | Jiang, Cheng-Shi(bio_jiangcs@ujn.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Two new highly oxygenated ergostane-type sterols (1, 2) together with one known related compound sinugrandisterol A (3) were isolated from the soft coral Sinularia sp. collected from the water area near the Xisha Islands, South China Sea. Their structures were elucidated on the basis of detailed spectroscopic analysis, chemical transformations, and by comparison with those reported in literature. In bioassays, compounds 1 and 2 showed in vitro antiproliferative activity against a panel of cancer cell lines, including MDA-MB-436, A549, Hep3B, HT-29 and H157. Morphological observation and Hoechst 33,258 staining assays showed that compound 1-treated H157 cells displayed apoptosis characteristics. Moreover, western blot assays suggested that 1 could increase the expression of Bax and down-regulate expression of Bcl-2. |
| WOS关键词 | POLYHYDROXYLATED STEROIDS ; TIRUCALLANE TRITERPENES ; ROOTS |
| 资助项目 | Drug Innovation Major Project[2018ZX09711-001-001-009] ; State Key Basic Research Program of the PRC[2018YFC0310903] ; NSFC-Shandong Joint Fund for Marine Science Research Center[U1606403] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; SKLDR/SIMM Project[SIMM1903ZZ-04] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000477788300013 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289205]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Cheng-Shi; Guo, Yue-Wei |
| 作者单位 | 1.Univ Jinan, Sch Biol Sci & Technol, 336 West Rd Nan Xinzhuang, Jinan 250022, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangiiang Hitech Pk, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Lead Cpds, Wenhai Rd, Qingdao 266237, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Cheng-Shi,Ru, Tong,Huan, Xia-Juan,et al. New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.[J]. STEROIDS,2019,149:5. |
| APA | Jiang, Cheng-Shi,Ru, Tong,Huan, Xia-Juan,Miao, Ze-Hong,&Guo, Yue-Wei.(2019).New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp..STEROIDS,149,5. |
| MLA | Jiang, Cheng-Shi,et al."New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.".STEROIDS 149(2019):5. |
入库方式： OAI收割
来源：上海药物研究所
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