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Engineering nanoparticles to locally activate T cells in the tumor microenvironment

文献类型：期刊论文

作者Wang, Dangge1,2,3,4; Wang, Tingting1,2,4; Yu, Haijun1,2,3; Feng, Bing1,2,4; Zhou, Lei1,2; Zhou, Fangyuan1,2; Hou, Bo1,2; Zhang, Hanwu1,2; Luo, Min5,6; Li, Yaping1,2,7
刊名SCIENCE IMMUNOLOGY
出版日期2019-07-01
卷号4期号:37页码:13
ISSN号2470-9468
DOI10.1126/sciimmunol.aau6584
通讯作者Yu, Haijun(hjyu@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Immunological tolerance of tumors is characterized by insufficient infiltration of cytotoxic T lymphocytes (CTLs) and immunosuppressive microenvironment of tumor. Tumor resistance to immune checkpoint inhibitors due to immunological tolerance is an ongoing challenge for current immune checkpoint blockade (ICB) therapy. Here, we report the development of tumor microenvironment-activatable anti-PDL1 antibody (alpha PDL1) nanoparticles for combination immunotherapy designed to overcome immunological tolerance of tumors. Combination of alpha PDL1 nanoparticle treatment with near-infrared (NIR) laser irradiation-triggered activation of photosensitizer indocyanine green induces the generation of reactive oxygen species, which promotes the intratumoral infiltration of CTLs and sensitizes the tumors to PDL1 blockade therapy. We showed that the combination of antibody nanoparticles and NIR laser irradiation effectively suppressed tumor growth and metastasis to the lung and lymph nodes in mouse models. The nanoplatform that uses the antibody nanoparticle alone both for immune stimulation and PDL1 inhibition could be readily adapted to other immune checkpoint inhibitors for improved ICB therapy.
WOS关键词PHOTODYNAMIC-THERAPY ; CHECKPOINT BLOCKADE ; PHOTOTHERMAL THERAPY ; INDOCYANINE GREEN ; DENDRITIC CELLS ; CANCER ; IMMUNOTHERAPY ; ANTI-PD-1 ; PEMBROLIZUMAB ; RESPONSES
资助项目National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[81521005] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2019283]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000476558700001
出版者AMER ASSOC ADVANCEMENT SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/289212]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China
6.Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China
7.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Dangge,Wang, Tingting,Yu, Haijun,et al. Engineering nanoparticles to locally activate T cells in the tumor microenvironment[J]. SCIENCE IMMUNOLOGY,2019,4(37):13.
APA Wang, Dangge.,Wang, Tingting.,Yu, Haijun.,Feng, Bing.,Zhou, Lei.,...&Li, Yaping.(2019).Engineering nanoparticles to locally activate T cells in the tumor microenvironment.SCIENCE IMMUNOLOGY,4(37),13.
MLA Wang, Dangge,et al."Engineering nanoparticles to locally activate T cells in the tumor microenvironment".SCIENCE IMMUNOLOGY 4.37(2019):13.

入库方式： OAI收割

来源：上海药物研究所

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