Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery
文献类型：期刊论文
| 作者 | Dai, Zhuo1,2; Yu, Miaorong2,3; Yi, Xin4,5; Wu, Zeming4,5; Tian, Falin6; Miao, Yunqiu1,2; Song, Wenyi2; He, Shufang2; Ahmad, Ejaj2; Guo, Shiyan2 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-07-01 |
| 卷号 | 13期号:7页码:7676-7689 |
| 关键词 | SUVs liposome chain length and saturation membrane mechanics vesicle rigidity ECM penetration tumor delivery |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b01181 |
| 通讯作者 | Yi, Xin(xyi@pku.edu.cn) ; Wang, Rui(ellewang@163.com) ; Gan, Yong(ygan@simm.ac.cn) |
| 英文摘要 | Small unilamellar vesicles (SUVs), ubiquitous in organisms, play key and active roles in various biological processes. Although the physical properties of the constituent lipid molecules (i.e., the acyl chain length and saturation) are known to affect the mechanical properties of SUVs and consequently regulate their biological behaviors and functions, the underlying mechanism remains elusive. Here, we combined theoretical modeling and experimental investigation to probe the mechanical behaviors of SUVs with different lipid compositions. The membrane bending rigidity of SUVs increased with increasing chain length and saturation, resulting in differences in the vesicle rigidity and deformable capacity. Furthermore, we tested the tumor delivery capacity of liposomes with low, intermediate, and high rigidity as typical models for SUVs. Interestingly, liposomes with intermediate rigidity exhibited better tumor extracellular matrix diffusion and multicellular spheroid (MCS) penetration and retention than that of their stiffer or softer counterparts, contributing to improved tumor suppression. Stiff SUVs had superior cellular internalization capacity but intermediate tumor delivery efficacy. Stimulated emission depletion microscopy directly showed that the optimal formulation was able to transform to a rod-like shape in MCSs, which stimulated fast transport in tumor tissues. In contrast, stiff liposomes hardly deformed, whereas soft liposomes changed their shape irregularly, which slowed their MCS penetration. Our findings introduce special perspectives from which to map the detailed mechanical properties of SUVs with different compositions, provide clues for understanding the biological functions of SUVs, and suggest that liposome mechanics may be a design parameter for enhancing drug delivery. |
| WOS关键词 | PANCREATIC-CANCER ; BENDING RIGIDITY ; DRUG PENETRATION ; LIPID VESICLES ; STELLATE CELLS ; NANOPARTICLES ; LIPOSOMES ; DIFFUSION ; MEMBRANES ; PRESSURE |
| 资助项目 | National Natural Science Foundation of China[81803445] ; National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[11872005] ; National Natural Science Foundation of China[81573378] ; National Natural Science Foundation of China[81773651] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Science and Technology Commission of Shanghai Municipality[17430741500] ; Shanghai Science and Technology Committee[18430721600] ; program of the Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine ; K.C. Wong Education Foundation ; New Star Program, Shanghai Institute of Materia Medica, CAS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000477786400032 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289223]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yi, Xin; Wang, Rui; Gan, Yong |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Peking Univ, Beijing Innovat Ctr Engn Sci & Adv Technol, Coll Engn, Beijing 100871, Peoples R China 5.Peking Univ, Dept Mech & Engn Sci, Coll Engn, Beijing 100871, Peoples R China 6.Chinese Acad Sci, CAS Key Lab Nanosyst & Hierarchy Fabricat, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Zhuo,Yu, Miaorong,Yi, Xin,et al. Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery[J]. ACS NANO,2019,13(7):7676-7689. |
| APA | Dai, Zhuo.,Yu, Miaorong.,Yi, Xin.,Wu, Zeming.,Tian, Falin.,...&Gan, Yong.(2019).Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery.ACS NANO,13(7),7676-7689. |
| MLA | Dai, Zhuo,et al."Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery".ACS NANO 13.7(2019):7676-7689. |
入库方式： OAI收割
来源：上海药物研究所
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