Dissecting the Metabolic Phenotype of the Antihypertensive Effects of Five Uncaria Species on Spontaneously Hypertensive Rats
文献类型：期刊论文
| 作者 | Feng, Zijin1; Hou, Jinjun2 ; Yu, Yang2; Wu, Wenyong2; Deng, Yanping2; Wang, Xia2; Zhi, Haijuan2; Zhang, Linlin2; Wu, Wanying2; Guo, De-an1,2
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| 刊名 | FRONTIERS IN PHARMACOLOGY
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| 出版日期 | 2019-07-30 |
| 卷号 | 10页码:11 |
| 关键词 | Uncaria Stem with Hooks multiple botanical origins spontaneously hypertensive rats systolic blood pressure metabonomics indole alkaloids |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2019.00845 |
| 通讯作者 | Wu, Wanying(wanyingwu@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | The sourcing of plants from multiple botanical origins is a common phenomenon in traditional Chinese medicines. Uncaria Stem with Hooks (UHs) are approved for using five botanical origins in the Chinese Pharmacopoeia (2015 Edition). All five UHs are commonly used for treating hypertension even though the plants have different chromatographic fingerprints based on our previous study. However, their hypotensive effects and metabolic phenotypes have not been fully studied. In the present study, spontaneously hypertensive rats (SHRs) were orally administered five aqueous extracts (4 g crude drug/kg) prepared from the different UHs over a 6-week period. Systolic blood pressure (SBP) was measured every week, and urine was collected after SBP measurement. Untargeted metabonomics was performed using ultra performance liquid chromatography (UPLC) coupled with an LTQ-Orbitrap mass spectrometer. Bidirectional orthogonal projection to latent structures discriminant analysis (O2PLS-DA), Student's t test, and correlation analysis were used for pattern recognition and the selection of significant metabolites. A similar and prolonged reduction in SBP was observed in each of the groups given the five different UHs, while the metabolic profiles were perturbed slightly compared with that of SHR. Further analysis has shown that only a few common, different components were observed within the five groups, which showed the similar antihypertensive effect in spite of the distinct metabolic pathways due to their different alkaloid composition. These results help in understanding the mechanisms of the phenomenon "different species, same effect" of UHs. |
| WOS关键词 | SUANZAOREN DECOCTION ; METABONOMICS ; DISCOVERY ; INSOMNIA ; EXTRACT ; BLOOD |
| 资助项目 | National Natural Science Foundation of China[81673591] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000477794800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289232]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Wanying; Guo, De-an |
| 作者单位 | 1.China Pharmaceut Univ, Coll Tradit Chinese Med, Nanjing, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Zijin,Hou, Jinjun,Yu, Yang,et al. Dissecting the Metabolic Phenotype of the Antihypertensive Effects of Five Uncaria Species on Spontaneously Hypertensive Rats[J]. FRONTIERS IN PHARMACOLOGY,2019,10:11. |
| APA | Feng, Zijin.,Hou, Jinjun.,Yu, Yang.,Wu, Wenyong.,Deng, Yanping.,...&Guo, De-an.(2019).Dissecting the Metabolic Phenotype of the Antihypertensive Effects of Five Uncaria Species on Spontaneously Hypertensive Rats.FRONTIERS IN PHARMACOLOGY,10,11. |
| MLA | Feng, Zijin,et al."Dissecting the Metabolic Phenotype of the Antihypertensive Effects of Five Uncaria Species on Spontaneously Hypertensive Rats".FRONTIERS IN PHARMACOLOGY 10(2019):11. |
入库方式： OAI收割
来源：上海药物研究所
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