Recyclable and Stable alpha-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected alpha-Amino Acids
文献类型：期刊论文
| 作者 | Shu, Shuangjie; Zhao, Liang; Zhou, Shengbin; Wu, Chenglin; Liu, Hong ; Wang, Jiang
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2019-06-02 |
| 卷号 | 24期号:12页码:19 |
| 关键词 | quaternary carbon dynamic kinetic resolution unprotected alpha-amino acids Schiff base intermediates ligands |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules24122218 |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Wang, Jiang(jwang@simm.ac.cn) |
| 英文摘要 | A novel special designed, stable, and recyclable chiral ligand bearing a quaternary carbon was developed for chemical dynamic kinetic resolution (DKR) of free C,N-unprotected racemic alpha-amino acids via Schiff base intermediates. This method furnishes high yields with excellent enantioselectivity, has a broad substrate scope, and uses operationally simple and convenient conditions. The present chemical DKR is a practical and useful method for the preparation of enantiopure alpha-amino acids. |
| 资助项目 | National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21602234] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81620108027] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000473816900024 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289244]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Wang, Jiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Shuangjie,Zhao, Liang,Zhou, Shengbin,et al. Recyclable and Stable alpha-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected alpha-Amino Acids[J]. MOLECULES,2019,24(12):19. |
| APA | Shu, Shuangjie,Zhao, Liang,Zhou, Shengbin,Wu, Chenglin,Liu, Hong,&Wang, Jiang.(2019).Recyclable and Stable alpha-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected alpha-Amino Acids.MOLECULES,24(12),19. |
| MLA | Shu, Shuangjie,et al."Recyclable and Stable alpha-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected alpha-Amino Acids".MOLECULES 24.12(2019):19. |
入库方式： OAI收割
来源：上海药物研究所
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