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CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway

文献类型：期刊论文

作者Liu, Jianan1,2; Yang, Li1; Liu, Feifei1; Li, Heng1; Tang, Wei1; Tong, Xiankun1; Zuo, Jianping1,2,3
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2019-07-30
卷号515期号:3页码:403-409
关键词CNOT2 Dengue virus IFN JAK-STAT pathway ISGs
ISSN号0006-291X
DOI10.1016/j.bbrc.2019.05.083
通讯作者Tong, Xiankun(xktong@simm.ac.cn) ; Zuo, Jianping(jpzuo@simm.ac.cn)
英文摘要Dengue virus (DENV) infection is a public health problem worldwide. To establish infection in host cells, DENV require host cellular mechanism to suppress and evade innate immunity for their replication. In this study, Ccr4-Not complex genes were screened by using RNAi approach in DENV-infected A549 and Huh7 cells. We found that CNOT2 plays a proviral role in DENV infection. The expression level of CNOT2 was up-regulated in DENV-infected cells. Down-regulation of CNOT2 significantly reduced DENV RNA replication and protein synthesis. Mechanism study showed that CNOT2 knockdown enhanced JAK-STAT antiviral signaling during DENV infection. Further analysis revealed that CNOT2 negatively modulated IFN-Independent Non-Canonical JAK/STAT pathway by accelerating the mRNA decay of JAK1 and STAT1 via its interaction with CNOT6/6L and CNOT7/8 deadenylases. Overall, these results demonstrate that CNOT2 is a novel negative regulator of the JAK-STAT pathway and supports DENV infection. (C) 2019 Elsevier Inc. All rights reserved.
WOS关键词MESSENGER-RNA DECAY ; JAK-STAT PATHWAY ; CCR4-NOT COMPLEX ; DEADENYLATION
资助项目National Key Research and Development Program of China[2018YFC1200604] ; Key Project of Chineses Academy of Sciences[KGFZD-135-18-020]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000472986400001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/289282]  
专题中国科学院上海药物研究所
通讯作者Tong, Xiankun; Zuo, Jianping
作者单位1.Chinese Acad Sci, Shanghai Inst Materia Med, Lab Immunopharmacol, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Jianan,Yang, Li,Liu, Feifei,et al. CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,515(3):403-409.
APA Liu, Jianan.,Yang, Li.,Liu, Feifei.,Li, Heng.,Tang, Wei.,...&Zuo, Jianping.(2019).CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,515(3),403-409.
MLA Liu, Jianan,et al."CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 515.3(2019):403-409.

入库方式： OAI收割

来源：上海药物研究所

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