CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading
文献类型：期刊论文
| 作者 | Ding, Huanyu1,2; Wu, Li2; Guo, Tao2; Zhang, Zaiyong2; Garba, Bello Mubarak2; Gao, Ge2; He, Siyu2; Zhang, Wei2; Chen, Yizhi3; Lin, Yangjing3 |
| 刊名 | CRYSTAL GROWTH & DESIGN
 |
| 出版日期 | 2019-07-01 |
| 卷号 | 19期号:7页码:3888-3894 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/acs.cgd.9b00319 |
| 通讯作者 | Liu, Hewen(lhewen@ustc.edu.cn) ; Anwar, Jamshed(j.anwar@lancaster.ac.uk) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate gamma-cyclodextrin metal-organic framework (gamma-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense gamma-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense gamma-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N-2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of gamma-CD-MOFs in drug loading and other potential fields. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; SINGLE-CRYSTAL ; ADSORPTION ; CAGES |
| 资助项目 | National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2018ZX09721002-009] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA12050307] ; National Natural Science Foundation of China[81430087] ; National Natural Science Foundation of China[81803441] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000474669900033 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289316]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Hewen; Anwar, Jamshed; Zhang, Jiwen |
| 作者单位 | 1.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 3.Hainan Hualon Pharmaceut Co Ltd, Haikou 570311, Hainan, Peoples R China 4.Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China 5.Univ Lancaster, Dept Chem, Chem Theory & Computat, Lancaster LA1 4YB, England |
| 推荐引用方式 GB/T 7714 | Ding, Huanyu,Wu, Li,Guo, Tao,et al. CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading[J]. CRYSTAL GROWTH & DESIGN,2019,19(7):3888-3894. |
| APA | Ding, Huanyu.,Wu, Li.,Guo, Tao.,Zhang, Zaiyong.,Garba, Bello Mubarak.,...&Zhang, Jiwen.(2019).CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading.CRYSTAL GROWTH & DESIGN,19(7),3888-3894. |
| MLA | Ding, Huanyu,et al."CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading".CRYSTAL GROWTH & DESIGN 19.7(2019):3888-3894. |
入库方式： OAI收割
来源：上海药物研究所
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