Study of pharmacokinetics and cutaneous photosensitization of hemoporfin in healthy volunteers
文献类型：期刊论文
| 作者 | Xu, Junyu1; Zhao, Xia1; Wu, Yan2; Tu, Ping2; Sun, Peihong1; Zhou, Ying1; Liang, Yan1; Chen, Xiaoyan3 ; Zhang, Yifan3; Cui, Yimin1
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| 刊名 | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
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| 出版日期 | 2019-06-01 |
| 卷号 | 26页码:116-123 |
| 关键词 | Hemoporfin Pharmacokinetics Photosensitization Mass balance Haematoporphyrin |
| ISSN号 | 1572-1000 |
| DOI | 10.1016/j.pdpdt.2019.02.023 |
| 通讯作者 | Cui, Yimin(cuiymzy@126.com) ; Tao, Jining(jntao@fd-zj.com) |
| 英文摘要 | Background: Hemoporfin is a porphyrin-based photosensitizer and has been used for photodynamic therapy of port wine stain birthmarks in China. This study assessed the pharmacokinetics and cutaneous photosensitization of Hemoporfin in healthy volunteers. Methods: Sixteen healthy subjects received a single intravenous infusion injection of Hemoporfin (5 mg/kg). The concentrations of Hemoporfin (MHD) and its metabolite Haematoporphyrin (HP) in plasma, urine and faeces were determined. The pharmacokinetic parameters were calculated. In addition, the cutaneous photo sensitization was evaluated under the irradiation of solar simulator, 532 nm laser, and sunlight. Results: The C-max of MHD and HP were 46.7 +/- 8.41 and 1.04 +/- 0.265 mu g/ml, respectively. The t(1/2) of MHD and HP were 5.09 +/- 0.945 and 5.71 +/- 2.65 h, respectively. The AUC(0.24h) of MHD and HP were 29.8 +/- 6.19 and 0.757 +/- 0.285 h.mu g/ml, respectively. The AUC(0-infinity) of MHD and HP were 29.8 +/- 6.2 and 0.792 +/- 0.308 h.mu g/ml, respectively. The cumulative fecal excretion rate of MHD and HP were 45.3% and 1.05% at 96 h, respectively. Whereas, the cumulative urinary excretion rate of MHD was only 0.132% at 96 h. The concentration of HP in urine was less than 10% of MHD. After 52 h of administration, the cutaneous photosensitization associated with the exposure to various light sources was minimal. Conclusion: MHD and HP were excreted mainly through the faeces after intravenous infusion. Hemoporfin associated cutaneous photosensitization was insignificant. |
| WOS关键词 | PHOTODYNAMIC THERAPY PDT ; WINE STAIN PWS ; SKIN ; CANCER ; HMME |
| 资助项目 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000474330400022 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289327]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cui, Yimin; Tao, Jining |
| 作者单位 | 1.Peking Univ, Dept Pharm, Hosp 1, Beijing 100034, Peoples R China 2.Peking Univ, Dept Dermatol & Venereol, Hosp 1, Beijing 100034, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab & Pharmacokinet Res, Shanghai 201203, Peoples R China 4.Shanghai Fudan Zhangjiang Biopharmaceut Co Ltd, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Junyu,Zhao, Xia,Wu, Yan,et al. Study of pharmacokinetics and cutaneous photosensitization of hemoporfin in healthy volunteers[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2019,26:116-123. |
| APA | Xu, Junyu.,Zhao, Xia.,Wu, Yan.,Tu, Ping.,Sun, Peihong.,...&Tao, Jining.(2019).Study of pharmacokinetics and cutaneous photosensitization of hemoporfin in healthy volunteers.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,26,116-123. |
| MLA | Xu, Junyu,et al."Study of pharmacokinetics and cutaneous photosensitization of hemoporfin in healthy volunteers".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 26(2019):116-123. |
入库方式： OAI收割
来源：上海药物研究所
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