SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC
文献类型：期刊论文
| 作者 | Zhang, Sulin1,2; Yang, Zhiwen3; Bao, Weilian1; Liu, Lixin1; You, Yan1; Wang, Xu1; Shao, Liming1; Fu, Wei1; Kou, Xinhui1; Shen, Weixing4 |
| 刊名 | AUTOPHAGY
 |
| 出版日期 | 2019-07-05 |
| 页码 | 15 |
| 关键词 | Colorectal cancer macroautophagy SNX10 SRC tumor growth |
| ISSN号 | 1554-8627 |
| DOI | 10.1080/15548627.2019.1632122 |
| 通讯作者 | Zheng, Mingyue(myzheng@simm.ac.cn) ; Shen, Xiaoyan(shxiaoy@fudan.edu.cn) |
| 英文摘要 | The non-receptor tyrosine kinase SRC is a key mediator of cellular protumorigenic signals. SRC is aberrantly over-expressed and activated in more than 80% of colorectal cancer (CRC) patients, therefore regulation of its stability and activity is essential. Here, we report a significant down regulation of SNX10 (sorting nexin 10) in human CRC tissues, which is closely related to tumor differentiation, TNM stage, lymph node metastasis and survival period. SNX10 deficiency in normal and neoplastic colorectal epithelial cells promotes initiation and progression of CRC in mice. SNX10 controls SRC levels by mediating autophagosome-lysosome fusion and SRC recruitment for autophagic degradation. These mechanisms ensure proper controlling of the activities of SRC-STAT3 and SRC-CTNNB1 signaling pathways by up-regulating SNX10 expression under stress conditions. These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development. |
| WOS关键词 | CHAPERONE-MEDIATED AUTOPHAGY ; STAT3 ; EXPRESSION ; INFLAMMATION ; ACTIVATION ; REVEALS ; ROLES ; CELLS ; MODEL ; IL-6 |
| 资助项目 | National Natural Science Foundation of China[81773744] ; National Natural Science Foundation of China[81573441] ; National Natural Science Foundation of China[81371923] ; China Postdoctoral Science Foundation[2018M642122] ; Shanghai Sailing Program[19YF1457800] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000475048000001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289346]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zheng, Mingyue; Shen, Xiaoyan |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacol, 826 Zhangheng Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 1, Songjiang Hosp, Dept Pharm, Shanghai, Peoples R China 4.Nanjing Univ Tradit Chinese Med, Translat Med Res Ctr, Nanjing, Jiangsu, Peoples R China 5.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Sulin,Yang, Zhiwen,Bao, Weilian,et al. SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC[J]. AUTOPHAGY,2019:15. |
| APA | Zhang, Sulin.,Yang, Zhiwen.,Bao, Weilian.,Liu, Lixin.,You, Yan.,...&Shen, Xiaoyan.(2019).SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.AUTOPHAGY,15. |
| MLA | Zhang, Sulin,et al."SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC".AUTOPHAGY (2019):15. |
入库方式： OAI收割
来源：上海药物研究所
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