Synthesis and In Vitro Antibacterial Activity of Novel Naphthyridinone Derivatives
文献类型：期刊论文
| 作者 | Sun, Bin1; Chen, Jianwei2; Ye, Fei3; Lu, Yaojia2; Xu, Guiqing3; Mao, Longfei4; Gao, Yuan4; Zhang, Huawei2; Wang, Hong2,5; Peng, Lizeng6 |
| 刊名 | CHEMISTRYSELECT
 |
| 出版日期 | 2019-06-07 |
| 卷号 | 4期号:21页码:6552-6556 |
| ISSN号 | 2365-6549 |
| 关键词 | antibacterial activity C violaceum ATCC 12472 naphthyridinone derivatives quorum sensing inhibitory activity synthesis |
| DOI | 10.1002/slct.201803532 |
| 通讯作者 | Wang, Hong(hongw@zjut.edu.cn) ; Peng, Lizeng(asiapharmacc@163.com) |
| 英文摘要 | Naphthyridinone has been reported exhibiting strong antibacterial activity. Now, this study describes a series of novel hydrochloride salts of 5,6,7,8-tetrahydro-1,6-naphthyridin-2-(1H)-one derivatives (10 a-10 l) as potential antibacterial agents and corresponding synthetic routes. The majority of analogues exhibit antibacterial activity against Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus). Several of them (10 a, 10 b, 10 h and 10 i) showed strongly antibacterial activity towards E. coli. Compound 10 l is also the first reported compound to exhibit quorum sensing inhibitory activity against C. violaceum ATCC 12472. The presence of quorum sensing inhibitory compound indicates its potential use in the treatment of bacterial infections. |
| 资助项目 | National Key Research and Development Program of China[2017YFE0103100] ; National Natural Science Foundation of China[81773628] ; National Natural Science Foundation of China[41776139] ; National Key R&D Program of China[2018YFC0311003] ; China Postdoctoral Science Foundation[2017 M620254] ; Zhejiang Postdoctoral Science Foundation ; Foundation of Key Laboratory of Marine Ecosystem and Biogeochemistry, SOA[LMEB201501] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000471074700020 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289450]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hong; Peng, Lizeng |
| 作者单位 | 1.Shandong Normal Univ, Key Lab Mol & Nano Probes, Minist Educ, Coll Chem Chem Engn & Mat Sci,Collaborat Innovat, Jinan 250014, Shandong, Peoples R China 2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China 3.Chinese Acad, Shanghai Inst Mat Med, State Key Lab Drug Res, Coll Life Sci,Zhejiang Sci Tech Univ & Drug Disco, Shanghai, Peoples R China 4.Henan Normal Univ, Henan Engn Res Ctr Chiral Hydroxyl Pharmaceut, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China 5.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China 6.Jinan Asia Pharma Tech Co LTD, Jinan 250000, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Bin,Chen, Jianwei,Ye, Fei,et al. Synthesis and In Vitro Antibacterial Activity of Novel Naphthyridinone Derivatives[J]. CHEMISTRYSELECT,2019,4(21):6552-6556. |
| APA | Sun, Bin.,Chen, Jianwei.,Ye, Fei.,Lu, Yaojia.,Xu, Guiqing.,...&Peng, Lizeng.(2019).Synthesis and In Vitro Antibacterial Activity of Novel Naphthyridinone Derivatives.CHEMISTRYSELECT,4(21),6552-6556. |
| MLA | Sun, Bin,et al."Synthesis and In Vitro Antibacterial Activity of Novel Naphthyridinone Derivatives".CHEMISTRYSELECT 4.21(2019):6552-6556. |
入库方式： OAI收割
来源：上海药物研究所
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