Crystal Transformation of -CD-MOF Facilitates Loading of Dimercaptosuccinic Acid
文献类型：期刊论文
| 作者 | Xiong, Yuehuai1,2; Wu, Li2; Guo, Tao2; Wang, Caifen2; Wu, Wenting1; Tang, Yan1,2; Xiong, Ting1,2; Zhou, Yong1,2; Zhu, Weifeng1; Zhang, Jiwen1,2
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| 刊名 | AAPS PHARMSCITECH
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| 出版日期 | 2019-08-01 |
| 卷号 | 20期号:6页码:9 |
| 关键词 | beta-cyclodextrin metal-organic frameworks crystal transformation drug loading dimercaptosuccinic acid |
| ISSN号 | 1530-9932 |
| DOI | 10.1208/s12249-019-1422-z |
| 通讯作者 | Zhu, Weifeng(zwf0322@126.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | The -cyclodextrin-metal-organic framework (-CD-MOF), a potential drug delivery carrier, presents a densely packed laminated crystal structure (CCDC number 1041782) that prevents drug from entering inside the molecular voids in most CD units. In this paper, it was demonstrated that dimercaptosuccinic acid (DMSA), an instable small molecule chemical drug, was successfully loaded in -CD-MOF with a high molar ratio of 1:1.35 (-CD-MOF:DMSA) determined by high-performance liquid chromatography. The drug loading mechanism of -CD-MOF/DMSA was supported by a series of experimental characterizations and molecular simulations. The morphology observations revealed that crystalline particles of -CD-MOF transformed to reticular microstructure after drug loading evidenced by powder X-ray diffraction (PXRD), scanning electron microscope (SEM), synchrotron radiation Fourier transform infrared spectroscopy (SR-FTIR), and etc. It is of interest to note that the stability of DMSA was well improved by -CD-MOF, but decreased by -CD-MOF, indicating different protective capacities between the two types of CD-MOFs. Thus, it is hypothesized that the transformation from laminated molecular arrangement of -CD-MOF to reticular microstructure leads to an enhanced drug-loading capability for delivery of specific drugs. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; DMSA ; ADSORPTION ; DRUG |
| 资助项目 | National Science and Technology Major Projects for Major New Drugs Innovation and Development[2018ZX09721002-009] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000472001000001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289503]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, Weifeng; Zhang, Jiwen |
| 作者单位 | 1.Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang 330004, Jiangxi, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Yuehuai,Wu, Li,Guo, Tao,et al. Crystal Transformation of -CD-MOF Facilitates Loading of Dimercaptosuccinic Acid[J]. AAPS PHARMSCITECH,2019,20(6):9. |
| APA | Xiong, Yuehuai.,Wu, Li.,Guo, Tao.,Wang, Caifen.,Wu, Wenting.,...&Zhang, Jiwen.(2019).Crystal Transformation of -CD-MOF Facilitates Loading of Dimercaptosuccinic Acid.AAPS PHARMSCITECH,20(6),9. |
| MLA | Xiong, Yuehuai,et al."Crystal Transformation of -CD-MOF Facilitates Loading of Dimercaptosuccinic Acid".AAPS PHARMSCITECH 20.6(2019):9. |
入库方式： OAI收割
来源：上海药物研究所
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