Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties
文献类型：期刊论文
| 作者 | Zhou, Wen-Xiu1,2; Zhao, Hong-Wei1; Chen, Huan-Huan1; Zhang, Zai-Yong1; Chen, Dong-Ying1
|
| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2019-07-07 |
| 卷号 | 21期号:25页码:3770-3773 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/c9ce00377k |
| 通讯作者 | Chen, Dong-Ying(dychen@simm.ac.cn) |
| 英文摘要 | A drug-drug salt was prepared consisting of metformin and aspirin with two crystalline phases characterized. A hydrophilic surface induced recrystallization mechanism was supposed for the transition from anhydrate to hemihydrate. The modulated solubility properties of the dual drug would help to overcome the associated gastrointestinal side effects to some extent. |
| WOS关键词 | COCRYSTALLIZATION ; CRYSTALS |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000472682800002 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289522]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Dong-Ying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Res Ctr Pharmaceut Qual Control & Solid State Che, 555 Rd Zuchongzhi, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wen-Xiu,Zhao, Hong-Wei,Chen, Huan-Huan,et al. Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties[J]. CRYSTENGCOMM,2019,21(25):3770-3773. |
| APA | Zhou, Wen-Xiu,Zhao, Hong-Wei,Chen, Huan-Huan,Zhang, Zai-Yong,&Chen, Dong-Ying.(2019).Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties.CRYSTENGCOMM,21(25),3770-3773. |
| MLA | Zhou, Wen-Xiu,et al."Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties".CRYSTENGCOMM 21.25(2019):3770-3773. |
入库方式： OAI收割
来源：上海药物研究所
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