Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma
文献类型：期刊论文
| 作者 | Lei, Li1; Xu, Zhiai1; Hu, Xianli1; Lai, Yi1; Xu, Jie1; Hou, Bo2,3; Wang, Ya1; Yu, Haijun2,3 ; Tian, Yang1; Zhang, Wen1
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| 刊名 | SMALL
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| 出版日期 | 2019-05-01 |
| 卷号 | 15期号:22页码:11 |
| 关键词 | combination therapy imaging-guided treatment multivalent targeting peptide nanotubes sialic acid |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201900157 |
| 通讯作者 | Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn) ; Zhang, Wen(wzhang@chem.ecnu.edu.cn) |
| 英文摘要 | Tumor metastasis is considered a major cause of cancer-related human mortalities. However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent nanoplatform for the highly effective treatment of the metastatic melanoma is reported. The versatile nanoplatform is designed by integrating indocyanine green and a chemotherapeutic drug (7-ethyl-10-hydroxycamptothecin) into phenylboronic acid (PBA)-functionalized peptide nanotubes (termed as I/S-PPNTs). I/S-PPNTs precisely target tumor cells through multivalent interaction between PBA and overexpressed sialic acid on the tumor surface in order to achieve imaging-guided combination therapy. It is demonstrated that I/S-PPNTs are efficiently internalized by the B16-F10 melanoma cells in vitro in a PBA grafting density-dependent manner. It is further shown that I/S-PPNTs specifically accumulate and deeply penetrate into both the subcutaneous and lung metastatic B16-F10 melanoma tumors. More importantly, I/S-PPNT-mediated combination chemo-and photodynamic therapy efficiently eradicates tumor and suppresses the lung metastasis of B16-F10 melanoma in an immunocompetent C57BL/6 mouse model. The results highlight the promising potential of the multivalent peptide nanotubes for active tumor targeting and imaging-guided cancer therapy. |
| WOS关键词 | MULTIDRUG-RESISTANCE ; TUMOR-METASTASIS ; CELL-MEMBRANE ; CANCER ; NANOPARTICLES ; DESIGN ; CHEMOTHERAPY ; DOXORUBICIN ; RECOGNITION ; RECEPTOR |
| 资助项目 | National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[21775046] ; National Natural Science Foundation of China[21635003] ; National Natural Science Foundation of China[31622025] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000470928000016 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289570]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Zhiai; Yu, Haijun; Zhang, Wen |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Medica, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Li,Xu, Zhiai,Hu, Xianli,et al. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma[J]. SMALL,2019,15(22):11. |
| APA | Lei, Li.,Xu, Zhiai.,Hu, Xianli.,Lai, Yi.,Xu, Jie.,...&Zhang, Wen.(2019).Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma.SMALL,15(22),11. |
| MLA | Lei, Li,et al."Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma".SMALL 15.22(2019):11. |
入库方式： OAI收割
来源：上海药物研究所
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