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Rhodium(III)-Catalyzed [4+2] Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides

文献类型：期刊论文

作者Song, Xiaohan1,2,3; Han, Xu1,2,3; Zhang, Rui1,2,3; Liu, Hong1,2,3; Wang, Jiang1,2,3
刊名MOLECULES
出版日期2019-05-02
卷号24期号:10页码:17
关键词rhodium(III) sulfoxonium ylides naphthols
ISSN号1420-3049
DOI10.3390/molecules24101884
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Wang, Jiang(jwang@simm.ac.cn)
英文摘要A convenient Rh(III)-catalyzed C-H activation and cascade [4+2] annulation for the synthesis of naphthalenone sulfoxonium ylides has been developed. This method features perfect regioselectivity, mild and redox-neutral reaction conditions, and broad substrate tolerance with good to excellent yields. Preliminary mechanistic experiments were conducted and a plausible reaction mechanism was proposed. The new type naphthalenone sulfoxonium ylides could be further transformed into multi-substituted naphthols, which demonstrates the practical utility of this methodology.
WOS关键词ADRENERGIC BLOCKING-AGENTS ; CATALYZED SYNTHESIS ; DIONCOPHYLLINE ; FUNCTIONALIZATION ; DERIVATIVES ; NAPHTHOLS ; BOND
资助项目National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81620108027] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040107] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040201]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000470996600042
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/289579]  
专题新药研究国家重点实验室
通讯作者Liu, Hong; Wang, Jiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Song, Xiaohan,Han, Xu,Zhang, Rui,et al. Rhodium(III)-Catalyzed [4+2] Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides[J]. MOLECULES,2019,24(10):17.
APA Song, Xiaohan,Han, Xu,Zhang, Rui,Liu, Hong,&Wang, Jiang.(2019).Rhodium(III)-Catalyzed [4+2] Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides.MOLECULES,24(10),17.
MLA Song, Xiaohan,et al."Rhodium(III)-Catalyzed [4+2] Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides".MOLECULES 24.10(2019):17.

入库方式： OAI收割

来源：上海药物研究所

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